Edited by: Massimo De Felici and Susanna Dolci
Corrosion cast of mouse testis showing the arrival of convoluted seminiferous tubules to the rete testis (lacuna testis in the mouse) through the straight tubules. A constricted portion connecting both types of testicular tubules can be observed. Pluripotent stem cells of the testis (spermatogonia) are housed in specific niches at the level of the basal region of the convoluted seminiferous tubules. These niches, whose walls are lined with Sertoli cells and peritubular mioid cells (covered by a basal lamina and colagen fibers) create a microenvironment which participates in the regulation of the mitotic and metabolic activity of spermatogonia and are the seat of the onset of testicular germ cell tumors. For further details, see Silván et al. in this issue (pages 185-195).
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Male germ cells and cancer: a connection among pluripotency, differentiation and stem cell biology
Int. J. Dev. Biol. (2013) 57: 101-103
From testis to teratomas: a brief history of male germ cells in mammals
Int. J. Dev. Biol. (2013) 57: 115-121
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Perceiving signals, building networks, reprogramming germ cell fate
Int. J. Dev. Biol. (2013) 57: 123-132
Classification, epidemiology and therapies for testicular germ cell tumours
Int. J. Dev. Biol. (2013) 57: 133-139
Expression of FGFR3 during human testis development and in germ cell-derived tumours of young adults
Int. J. Dev. Biol. (2013) 57: 141-151
Int. J. Dev. Biol. (2013) 57: 153-157
Role of cyclins in controlling progression of mammalian spermatogenesis
Int. J. Dev. Biol. (2013) 57: 159-168
Cycling to and from a stem cell niche: the temporal and spatial odyssey of mitotic male germ cells
Int. J. Dev. Biol. (2013) 57: 169-177
Transcriptional control of KIT gene expression during germ cell development
Int. J. Dev. Biol. (2013) 57: 179-184
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The spermatogonial stem cell niche in testicular germ cell tumors
Int. J. Dev. Biol. (2013) 57: 185-195
Testicular germ cell tumors and related research from a historical point of view
Int. J. Dev. Biol. (2013) 57: 197-200
Testicular teratomas: an intersection of pluripotency, differentiation and cancer biology
Int. J. Dev. Biol. (2013) 57: 201-210
Int. J. Dev. Biol. (2013) 57: 211-219
Carcinoma in situ -from clinical observation to a paradigm shift for testicular carcinogenesis
Int. J. Dev. Biol. (2013) 57: 221-223
Endocrine disruptors, gene deregulation and male germ cell tumors
Int. J. Dev. Biol. (2013) 57: 225-239
Development of malignant germ cells - the genvironmental hypothesis
Int. J. Dev. Biol. (2013) 57: 241-253
Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence
Int. J. Dev. Biol. (2013) 57: 255-263
Int. J. Dev. Biol. (2013) 57: 265-272
Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumors
Int. J. Dev. Biol. (2013) 57: 273-280
UV and genotoxic stress induce ATR relocalization in mouse spermatocytes
Int. J. Dev. Biol. (2013) 57: 281-287
Pathobiology of germ cell tumors - applying the gossip test!
Int. J. Dev. Biol. (2013) 57: 289-298
Role of epigenetics in the etiology of germ cell cancer
Int. J. Dev. Biol. (2013) 57: 299-308
Int. J. Dev. Biol. (2013) 57: 309-317
Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer
Int. J. Dev. Biol. (2013) 57: 319-332