The International Journal of Developmental Biology

Volume 57 > Issue 2-3-4 (Special Issue)

Cover Vol. 57 N. 2-3-4

Male Germ Cells in Development & Tumors

Edited by: Massimo De Felici and Susanna Dolci

Cover Legend

Corrosion cast of mouse testis showing the arrival of convoluted seminiferous tubules to the rete testis (lacuna testis in the mouse) through the straight tubules. A constricted portion connecting both types of testicular tubules can be observed. Pluripotent stem cells of the testis (spermatogonia) are housed in specific niches at the level of the basal region of the convoluted seminiferous tubules. These niches, whose walls are lined with Sertoli cells and peritubular mioid cells (covered by a basal lamina and colagen fibers) create a microenvironment which participates in the regulation of the mitotic and metabolic activity of spermatogonia and are the seat of the onset of testicular germ cell tumors. For further details, see Silván et al. in this issue (pages 185-195).



Male germ cells and cancer: a connection among pluripotency, differentiation and stem cell biology

Massimo De Felici and Susanna Dolci

Int. J. Dev. Biol. (2013) 57: 101-103

Primodial germ cells, male germ cells and germ cell tumors

A lifetime of migration

Peter Donovan and Christopher Wylie

Int. J. Dev. Biol. (2013) 57: 105-113

From testis to teratomas: a brief history of male germ cells in mammals

Massimo De Felici and Susanna Dolci

Int. J. Dev. Biol. (2013) 57: 115-121


Perceiving signals, building networks, reprogramming germ cell fate

Florencia Barrios, Naoko Irie and M. Azim Surani

Int. J. Dev. Biol. (2013) 57: 123-132

Classification, epidemiology and therapies for testicular germ cell tumours

Nikhil Vasdev, Andrew Moon and Andrew C. Thorpe

Int. J. Dev. Biol. (2013) 57: 133-139

Expression of FGFR3 during human testis development and in germ cell-derived tumours of young adults

Katherine A. Ewen, Inge A. Olesen, Sofia B. Winge, Ana R. Nielsen, John E. Nielsen, Niels Graem, Anders Juul and Ewa Rajpert-De Meyts

Int. J. Dev. Biol. (2013) 57: 141-151

Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept

J.Wolter Oosterhuis, Suzanne H.P. Peeters, Vincent T.H.B.M. Smit, Hans Stoop, Leendert H.J. Looijenga, Henk W. Elzevier, Suzanne Osanto

Int. J. Dev. Biol. (2013) 57: 153-157

The control of male germ cell cycle and the spermatogonia stem cell “niche”

Role of cyclins in controlling progression of mammalian spermatogenesis

Debra J. Wolgemuth, Marcia Manterola and Ana Vasileva

Int. J. Dev. Biol. (2013) 57: 159-168

Cycling to and from a stem cell niche: the temporal and spatial odyssey of mitotic male germ cells

Christopher J. Payne

Int. J. Dev. Biol. (2013) 57: 169-177

Transcriptional control of KIT gene expression during germ cell development

Pellegrino Rossi

Int. J. Dev. Biol. (2013) 57: 179-184


The spermatogonial stem cell niche in testicular germ cell tumors

Unai Silván, Alejandro Díez-Torre, Pablo Moreno, Jon Arluzea, Ricardo Andrade, Margarita Silió and Juan Aréchaga

Int. J. Dev. Biol. (2013) 57: 185-195

Testicular teratomas and teratocarcinomas

Testicular germ cell tumors and related research from a historical point of view

Ivan Damjanov and Nicolai Wewer-Albrechtsen

Int. J. Dev. Biol. (2013) 57: 197-200

Testicular teratomas: an intersection of pluripotency, differentiation and cancer biology

Ximena Bustamante-Marín, Jason A. Garness and Blanche Capel

Int. J. Dev. Biol. (2013) 57: 201-210

Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors

Cassy M. Spiller, Josephine Bowles and Peter Koopman

Int. J. Dev. Biol. (2013) 57: 211-219

Environmental endocrine disruptors and germ cell tumors

Carcinoma in situ -from clinical observation to a paradigm shift for testicular carcinogenesis

Jorma Toppari

Int. J. Dev. Biol. (2013) 57: 221-223

Endocrine disruptors, gene deregulation and male germ cell tumors

Jesús Del Mazo, Miguel A. Brieño-Enríquez, Jesús García-López, Luis A. López-Fernández and Massimo De Felici

Int. J. Dev. Biol. (2013) 57: 225-239

Development of malignant germ cells - the genvironmental hypothesis

Leendert H.J. Looijenga, Ton Van Agthoven and Katharina Biermann

Int. J. Dev. Biol. (2013) 57: 241-253

Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence

Fabrizio Giannandrea, Donatella Paoli, Irene Figà-Talamanca, Francesco Lombardo, Andrea Lenzi and Loredana Gandini

Int. J. Dev. Biol. (2013) 57: 255-263

Male germ cell apoptosis and DNA damage

Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development

R. John Aitken and Mark A. Baker

Int. J. Dev. Biol. (2013) 57: 265-272

Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumors

Francesca Cavallo, Darren R. Feldman and Marco Barchi

Int. J. Dev. Biol. (2013) 57: 273-280

UV and genotoxic stress induce ATR relocalization in mouse spermatocytes

Sara Di Siena, Federica Campolo, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci and Manuela Pellegrini

Int. J. Dev. Biol. (2013) 57: 281-287

New insights into the molecular mechanisms of germ cell tumors: pluripotency genes, epigenetics and

Pathobiology of germ cell tumors - applying the gossip test!

Leendert H. J. Looijenga and J. Wolter Oosterhuis

Int. J. Dev. Biol. (2013) 57: 289-298

Role of epigenetics in the etiology of germ cell cancer

Yvonne G. Van Der Zwan, Hans Stoop, Fernando Rossello,Stefan J. White and Leendert H.J. Looijenga

Int. J. Dev. Biol. (2013) 57: 299-308

Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells

Dina G. Kristensen, Niels E. Skakkebæk, Ewa Rajpert-De Meyts and Kristian Almstrup

Int. J. Dev. Biol. (2013) 57: 309-317

Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer

Ronak Eini, Lambert C. J. Dorssers and Leendert H. J. Looijenga

Int. J. Dev. Biol. (2013) 57: 319-332