The International Journal of Developmental Biology

Int. J. Dev. Biol. 57: 221 - 223 (2013)

Vol 57, Issue 2-3-4

Special Issue: Male Germ Cells in Development & Tumors

Carcinoma in situ -from clinical observation to a paradigm shift for testicular carcinogenesis

Published: 30 May 2013

Jorma Toppari*

Departments of Physiology and Paediatrics, University of Turku, Turku, Finland and Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark


Carcinoma in situ in the testis has its origin in the fetal gonad and leads to testicular cancer in young adulthood. It can be detected in a testicular biopsy and treated with irradiation, which can preserve testosterone production of the man. These are the key findings of Niels E. Skakkebaek that changed our view of testicular tumourigenesis during the last fifty years. These and other findings are discussed in this interview-based review of testicular germ cell cancer.


testis, cancer, fertility, CIS, germ cell

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