The International Journal of Developmental Biology

Volume 53 > Issue 8-9-10 (Special Issue)

Cover Vol. 53 N. 8-9-10

Developmental Biology in Hispania (Spain & Portugal)

Edited by: Juan Aréchaga and Isabel Palmeirim

Cover Legend

In front of an old beautiful map from 1631, the pleasant time when Spain and Portugal still formed a unified country, stand a selection of representative figures of Hispanic Biological Morphology, Genetics and Biochemistry of all times. The actual progress of Developmental Biology in our countries cannot be understood without them. These seminal figures, background left to right, are: Severo Ochoa de Albornoz (1905-1993) Nobel Prize in 1959, Augusto Celestino Da Costa (1884-1956), José F. David-Ferreira (b.1929), Francisco Orts-Llorca (1905-1993), Aureliano Maestre de San Juan y Muñoz (1828-1890), Ignacio Bolívar y Urrutia (1850-1944), Antonio García-Bellido (b. 1936) and Antonio Gimbernat y Arbós (1734-1816); foreground, left to right: Juan Valverde de Amusco (ca. 1525-1588), Martín Martínez (1684-1736), Crisóstomo Martínez (1638-1694) and Santiago Ramón y Cajal (1852-1934) Nobel Prize in 1906.



Science in Hispania: Spain and Portugal on the main route again

Juan Aréchaga

Int. J. Dev. Biol. (2009) 53: 1119-1122

Introductory articles


Early bases of modern Embryology in Spain: Microscopical Anatomy and the introduction of Cell Theory and Histology in their scientific and social European context

Roberto Marco-Cuellar(†) and Juan Aréchaga

Int. J. Dev. Biol. (2009) 53: 1123-1143

Contributions to Neuroembryology of Santiago Ramon y Cajal (1852-1934) and Jorge F. Tello (1880-1958)

Luis Puelles

Int. J. Dev. Biol. (2009) 53: 1145-1160

Augusto Celestino da Costa (1884-1956) - professor, scientist and science promoter

José-Francisco David-Ferreira

Int. J. Dev. Biol. (2009) 53: 1161-1164


A glance at Spanish Embryology and Teratology during the XX Century through the academic life of Francisco Orts-Llorca (1905-1993)

Juan Aréchaga, Juan Jiménez-Collado and Domingo Ruano-Gil

Int. J. Dev. Biol. (2009) 53: 1165-1177

A perspective on the development of Genetics in Spain during the XX Century

Alfonso Martinez-Arias

Int. J. Dev. Biol. (2009) 53: 1179-1191

José-Antonio Campos-Ortega (1940-2004) and his scientific work - a personal perspective

Elisabeth Knust and Rainer Hertel

Int. J. Dev. Biol. (2009) 53: 1193-1203


A history of Evo-Devo research in Spain

Jaume Baguñà

Int. J. Dev. Biol. (2009) 53: 1205-1217


Plant Developmental Biology in Spain: from the origins to our days and prospects for the future

José-Pío Beltrán

Int. J. Dev. Biol. (2009) 53: 1219-1234

Teaching and research on Developmental Biology in Portugal

Sólveig Thorsteinsdóttir, Gabriela Rodrigues and Eduardo G. Crespo

Int. J. Dev. Biol. (2009) 53: 1235-1243

The teaching of Developmental Biology in Spain: future challenges

Manuel Marí-Beffa

Int. J. Dev. Biol. (2009) 53: 1245-1252

A personal account of the development of modern biological research in Portugal

Maria de Sousa

Int. J. Dev. Biol. (2009) 53: 1253-1259


A small great history of the sister Societies of Developmental Biology in Spain and Portugal

Isabel Palmeirim and Juan Aréchaga

Int. J. Dev. Biol. (2009) 53: 1261-1268

Iberia: from fable to the bench

Fernando Casares

Int. J. Dev. Biol. (2009) 53: 1269-1271


Idealism and romantic patriotism for science - an interview with José Francisco David-Ferreira

Maria Carmo-Fonseca and José Francisco David-Ferreira

Int. J. Dev. Biol. (2009) 53: 1273-1275


Ontogeny of an adventurous mind: the origin of Antonio García-Bellido’s contributions to developmental genetics

Alain Ghysen

Int. J. Dev. Biol. (2009) 53: 1277-1290

Special Review

The cellular and genetic bases of organ size and shape in Drosophila

Antonio García-Bellido

Int. J. Dev. Biol. (2009) 53: 1291-1303

Invited regular articles


Segmentation, metamerism and the Cambrian explosion

Juan Pablo Couso

Int. J. Dev. Biol. (2009) 53: 1305-1316


Planarian regeneration: achievements and future directions after 20 years of research

Emili Saló, Josep F. Abril, Teresa Adell, Francesc Cebriá, Kay Eckelt, Enrique Fernández-Taboada, Mette Handberg-Thorsager, Marta Iglesias, M Dolores Molina and Gustavo Rodríguez-Esteban

Int. J. Dev. Biol. (2009) 53: 1317-1327

Recent advances in Drosophila stem cell biology

John Pearson, Lourdes López-Onieva, Patricia Rojas-Ríos and Acaimo González-Reyes

Int. J. Dev. Biol. (2009) 53: 1329-1339

Apoptosis in Drosophila: compensatory proliferation and undead cells

Francisco A. Martín, Ainhoa Peréz-Garijo and Ginés Morata

Int. J. Dev. Biol. (2009) 53: 1341-1347

Genetic control of morphogenesis - Hox induced organogenesis of the posterior spiracles

James Castelli-Gair Hombría, María Luisa Rivas and Sol Sotillos

Int. J. Dev. Biol. (2009) 53: 1349-1358


From the American to the European amphioxus: towards experimental Evo-Devo at the origin of chordates

Jordi Garcia-Fernàndez, Senda Jiménez-Delgado, Juan Pascual-Anaya, Ignacio Maeso, Manuel Irimia, Carolina Minguillón, Èlia Benito-Gutiérrez, Josep Gardenyes, Stéphanie Bertrand and Salvatore D’Aniello

Int. J. Dev. Biol. (2009) 53: 1359-1366


Understanding the regulatory genome

M. Eva Alonso, Bárbara Pernaute, Miguel Crespo, José Luis Gómez-Skarmeta and Miguel Manzanares

Int. J. Dev. Biol. (2009) 53: 1367-1378

"Notch-Off": a perspective on the termination of Notch signalling

Rita Fior and Domingos Henrique

Int. J. Dev. Biol. (2009) 53: 1379-1384

Regulation and function of Spalt proteins during animal development

Jose F. de Celis and Rosa Barrio

Int. J. Dev. Biol. (2009) 53: 1385-1398

Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family

José António Belo, Ana C. Silva, Ana-Cristina Borges, Mário Filipe, Margaret Bento, Lisa Gonçalves, Marta Vitorino, Ana-Marisa Salgueiro, Vera Texeira, Ana T. Tavares and Sara Marques

Int. J. Dev. Biol. (2009) 53: 1399-1407


Function and specificity of Hox genes

David Foronda, Luis F. de Navas, Daniel L. Garaulet and Ernesto Sánchez-Herrero

Int. J. Dev. Biol. (2009) 53: 1409-1419

Portuguese contributions to the discovery and characterization of the embryonic molecular clock

Susana Pascoal and Isabel Palmeirim

Int. J. Dev. Biol. (2009) 53: 1421-1426

Building the vertebrate heart - an evolutionary approach to cardiac development

José M. Pérez-Pomares, Juan M. González-Rosa and Ramón Muñoz-Chápuli

Int. J. Dev. Biol. (2009) 53: 1427-1443

Movement and commitment of primitive streak precardiac cells during cardiogenesis

Carmen Lopez-Sanchez, Natividad Garcia-Masa, Carlos M. Gañan and Virginio Garcia-Martinez

Int. J. Dev. Biol. (2009) 53: 1445-1455


In vivo forced expression of myocardin in ventricular myocardium transiently impairs systolic performance in early neonatal pig heart

Mario Torrado, Alberto Centeno, Eduardo López and Alexander T. Mikhailov

Int. J. Dev. Biol. (2009) 53: 1457-1467

The road to the vertebral formula

Moisés Mallo, Tânia Vinagre and Marta Carapuço

Int. J. Dev. Biol. (2009) 53: 1469-1481

Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner

Nadia Mercader, Licia Selleri, Luis Miguel Criado, Pilar Pallares, Carlos Parras, Michael L. Cleary and Miguel Torres

Int. J. Dev. Biol. (2009) 53: 1483-1494

Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits

Carlos I. Lorda-Diez, Nuria Torre-Pérez, Juan A. García-Porrero, Juan M. Hurle and Juan A. Montero

Int. J. Dev. Biol. (2009) 53: 1495-1502

Patterning and cell fate in ear development

Berta Alsina, Fernando Giraldez and Cristina Pujades

Int. J. Dev. Biol. (2009) 53: 1503-1513


Early neural cell death: numbers and cues from the developing neuroretina

Ana I. Valenciano, Patricia Boya and Enrique J. de la Rosa

Int. J. Dev. Biol. (2009) 53: 1515-1528

Epiblast-derived stem cells in embryonic and adult tissues

Maria P. De-Miguel, Francisco Arnalich-Montiel, Pilar Lopez-Iglesias, Alejandro Blazquez-Martinez and Manuel Nistal

Int. J. Dev. Biol. (2009) 53: 1529-1540


Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives

M. Angela Nieto

Int. J. Dev. Biol. (2009) 53: 1541-1547

Epithelial resealing

Beatriz Garcia-Fernandez, Isabel Campos, Jennifer Geiger, Ana C. Santos and Antonio Jacinto

Int. J. Dev. Biol. (2009) 53: 1549-1556

Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer

Joana Caldeira, Paulo S. Pereira, Gianpaolo Suriano and Fernando Casares

Int. J. Dev. Biol. (2009) 53: 1557-1561


Reprogramming of melanoma cells by embryonic microenvironments

Alejandro Díez-Torre, Ricardo Andrade, Cristina Eguizábal, Elixabete López, Jon Arluzea, Margarita Silió and Juan Aréchaga

Int. J. Dev. Biol. (2009) 53: 1563-1568

Frontiers in fluorescence microscopy

José Rino, José Braga, Ricardo Henriques and Maria Carmo-Fonseca

Int. J. Dev. Biol. (2009) 53: 1569-1579

Chromatin remodeling in plant development

José A. Jarillo, Manuel Piñeiro, Pilar Cubas and José M. Martínez-Zapater

Int. J. Dev. Biol. (2009) 53: 1581-1596

Instructive roles for hormones in plant development

David Alabadí, Miguel A. Blázquez, Juan Carbonell, Cristina Ferrándiz and Miguel A. Pérez-Amador

Int. J. Dev. Biol. (2009) 53: 1597-1608

The role of ion fluxes in polarized cell growth and morphogenesis: the pollen tube as an experimental paradigm

Erwan Michard, Filipa Alves and José A. Feijó

Int. J. Dev. Biol. (2009) 53: 1609-1622


Lessons from a search for leaf mutants in Arabidopsis thaliana

José Manuel Pérez-Pérez, Héctor Candela, Pedro Robles, Víctor Quesada, María Rosa Ponce and José Luis Micol

Int. J. Dev. Biol. (2009) 53: 1623-1634

Genetic analysis of reproductive development in tomato

Rafael Lozano, Estela Giménez, Beatriz Cara, Juan Capel and Trinidad Angosto

Int. J. Dev. Biol. (2009) 53: 1635-1648

Genetic, molecular and cellular approaches to the analysis of maize embryo development

Matilde José-Estanyol, Ignacio López-Ribera, Miriam Bastida, Torben Jarhmann, Nuria Sánchez-Pons, Cristian Becerra, Carlos M. Vicient and Pere Puigdomènech

Int. J. Dev. Biol. (2009) 53: 1649-1654