Int. J. Dev. Biol. 53: 1409 - 1419 (2009)

https://doi.org/10.1387/ijdb.072462df

Vol 53, Issue 8-9-10

Special Issue: Developmental Biology in Hispania (Spain & Portugal)

Function and specificity of Hox genes

Open Access | Published: 1 November 2009

David Foronda, Luis F. de Navas, Daniel L. Garaulet and Ernesto Sánchez-Herrero*

Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Madrid, Spain

Abstract

The Hox genes specify different structures along the anteroposterior axis of bilaterians. They code for transcription factors including a conserved domain, the homeodomain, that binds DNA. The specificity of Hox function is determined by each gene controlling the expression of different groups of downstream genes. These can be other transcription factors, elements in signaling pathways or realizator genes that carry out basic cellular functions. In regulating specific targets, the Hox genes interact with members of signaling pathways and with other proteins, thus forming part of gene networks that contribute to the modification of homologous structures or to the creation of new organs.

Keywords

Hox, downstream gene, signaling, networks