Int. J. Dev. Biol. 58: 247 - 259 (2014)
Special Issue: Embryo Implantation
Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy
Published: 10 July 2014
Abstract
Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation. The hemochorial placenta facilitates the acquisition of maternal resources required for embryo/fetal growth. Uterine spiral arteries form the nutrient supply line for the placenta and fetus. This vascular conduit undergoes gestation stage-specific remodeling directed by maternal natural killer cells and embryo-derived invasive trophoblast lineages. The placentation site, including remodeling of the uterine spiral arteries, is shaped by environmental challenges. In this review, we discuss the cellular participants controlling pregnancy-dependent uterine spiral artery remodeling and mechanisms responsible for their development and function.
Keywords
hemochorial placentation, natural killer cell, trophoblast, PI3K/AKT, FOSL1, hypoxia, NOTCH, STOX1