Int. J. Dev. Biol. 55: 547 - 555 (2011)
Special Issue: Angiogenesis in Development & Cancer
The use of the orthotopic model to validate antivascular therapies for cancer
Review | Published: 19 July 2011
Abstract
The orthotopic model reproduces aspects of the tumour microenvironment and emulates a number of important biological features of cancer progression, angiogenesis, metastasis and resistance. Due to its parallels with human cancer, the model can be used to evaluate therapeutic responses to various therapies. This review outlines the importance of using the orthotopic implantation of tumour cells in mice models for evaluating the effectiveness of antivascular therapies.
Keywords
orthotopic model, vascular disrupting agent, antivascular therapy, cancer