The International Journal of Developmental Biology

Volume 55 > Issue 4-5 (Special Issue)

Cover Vol. 55 N. 4-5

Angiogenesis in Development & Cancer

Edited by: Domenico Ribatti and Valentin Djonov

Cover Legend

The Blood of the World (1927), oil on canvas by the surrealist Belgian artist René Magritte (1898-1967) who described his work as "visible images which conceal nothing; they evoke mystery and, indeed, when one sees one of my pictures, one asks oneself this simple question: what does that mean? It does not mean anything, because mystery means nothing either, it is unknowable". However, to the keen eye, this picture could be seen to represent the vital role of vasculogenesis for the normal development of organisms and for the pathological growth of tumors.



Angiogenesis in Development and Cancer Today

Domenico Ribatti and Valentin Djonov

Int. J. Dev. Biol. (2011) 55: 343-344

Introductory Papers

Evolution of angiogenesis

Ramón Muñoz-Chápuli

Int. J. Dev. Biol. (2011) 55: 345-351

Signal transduction in vasculogenesis and developmental angiogenesis

Sunita Patel-Hett and Patricia A. D’Amore

Int. J. Dev. Biol. (2011) 55: 353-363

The role of angiogenic growth factors in organogenesis

Enrico Crivellato

Int. J. Dev. Biol. (2011) 55: 365-375

A brief history of angiogenesis assays

Anca-Maria Cimpean, Domenico Ribatti and Marius Raica

Int. J. Dev. Biol. (2011) 55: 377-382


From the discovery of Vascular Endothelial Growth Factor to the introduction of Avastin in clinical trials - an interview with Napoleone Ferrara

Domenico Ribatti

Int. J. Dev. Biol. (2011) 55: 383-388

Fifteen years of molecular lymphangiogenesis - an interview with Kari Alitalo

Tatiana V. Petrova

Int. J. Dev. Biol. (2011) 55: 389-394

Anti-angiogenesis in cancer; met and unmet goals - an interview with Robert Kerbel

Francesco Bertolini

Int. J. Dev. Biol. (2011) 55: 395-398


Modeling of angioadaptation: insights for vascular development

Axel R. Pries, Bettina Reglin and Timothy W. Secomb

Int. J. Dev. Biol. (2011) 55: 399-405

Cell-based cardiovascular repair and regeneration in acute myocardial infarction and chronic ischemic cardiomyopathy – current status and future developments

Christian Templin, Thomas F. Lüscher and Ulf Landmesser

Int. J. Dev. Biol. (2011) 55: 407-417

The role of blood flow and microRNAs in blood vessel development

Dong Liu, Janna Krueger and Ferdinand Le Noble

Int. J. Dev. Biol. (2011) 55: 419-429

Hemangiomas - current therapeutic strategies

Peace Mabeta and Michael S. Pepper

Int. J. Dev. Biol. (2011) 55: 431-437

Nervous vascular parallels: axon guidance and beyond

Marco Arese, Guido Serini and Federico Bussolino

Int. J. Dev. Biol. (2011) 55: 439-445

Paracrine regulation of angiogenesis by different cell types in the aorta ring model

Roberto F. Nicosia, Penelope Zorzi, Giovanni Ligresti, Ann Morishita and Alfred C. Aplin

Int. J. Dev. Biol. (2011) 55: 447-453

Role of laminins in physiological and pathological angiogenesis

Patricia Simon-Assmann, Gertraud Orend, Elmina Mammadova-Bach, Caroline Spenlé and Olivier Lefebvre

Int. J. Dev. Biol. (2011) 55: 455-465

Current concepts of blood-brain barrier development

Stefan Liebner, Cathrin J. Czupalla and Hartwig Wolburg

Int. J. Dev. Biol. (2011) 55: 467-476

Cancer stem cells and angiogenesis

Yue Zhao, Qi Bao, Andrea Renner, Peter Camaj, Martin Eichhorn, Ivan Ischenko, Martin Angele, Axel Kleespies, Karl-Walter Jauch and Christiane Bruns

Int. J. Dev. Biol. (2011) 55: 477-482

Molecular mechanisms of lymphangiogenesis in development and cancer

Imke Albrecht and Gerhard Christofori

Int. J. Dev. Biol. (2011) 55: 483-494


The interplay between macrophages and angiogenesis in development, tissue injury and regeneration

Silvia Nucera, Daniela Biziato and Michele De Palma

Int. J. Dev. Biol. (2011) 55: 495-503

Zebrafish embryo, a tool to study tumor angiogenesis

Chiara Tobia, Giulia De Sena and Marco Presta

Int. J. Dev. Biol. (2011) 55: 505-509


Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth

Ellen Van Obberghen-Schilling, Richard P. Tucker, Falk Saupe, Isabelle Gasser, Botond Cseh, Gertraud Orend

Int. J. Dev. Biol. (2011) 55: 511-525

Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells

Julien Laurent, Cédric Touvrey, Francesca Botta, François Kuonen and Curzio Ruegg

Int. J. Dev. Biol. (2011) 55: 527-534

Tumor blood vessel visualization

Jeannine Missbach-Guentner, Julia Hunia and Frauke Alves

Int. J. Dev. Biol. (2011) 55: 535-546

The use of the orthotopic model to validate antivascular therapies for cancer

Monica Loi, Daniela Di Paolo, Pamela Becherini, Alessia Zorzoli, Patrizia Perri, Roberta Carosio, Michele Cilli, Domenico Ribatti, Chiara Brignole, Gabriella Pagnan, Mirco Ponzoni and Fabio Pastorino

Int. J. Dev. Biol. (2011) 55: 547-555

Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?

Yihai Cao

Int. J. Dev. Biol. (2011) 55: 557-562

Escape mechanisms after antiangiogenic treatment, or why are the tumors growing again?

Ruslan Hlushchuk, Andrew N. Makanya and Valentin Djonov

Int. J. Dev. Biol. (2011) 55: 563-567