The International Journal of Developmental Biology

Int. J. Dev. Biol. 55: 377 - 382 (2011)

Vol 55, Issue 4-5

Special Issue: Angiogenesis in Development & Cancer

A brief history of angiogenesis assays

Review | Published: 19 July 2011

Anca-Maria Cimpean*,1, Domenico Ribatti2 and Marius Raica1

1Department of Histology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania and 2Department of Human Anatomy and Histology, University of Bari Medical School, Italy


The major problem with angiogenesis research is the choice of an appropriate assay. Currently, many in vitro and in vivo techniques are available for research into the functions of endothelial cells during angiogenesis. In this historical review article, we describe and evaluate the methodology and specific features of some of the most frequently used of these assays.


angiogenesis assay, endothelial cell, in vtro model, in vivo model

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