Int. J. Dev. Biol. 55: 377 - 382 (2011)

https://doi.org/10.1387/ijdb.103215ac

Vol 55, Issue 4-5

Special Issue: Angiogenesis in Development & Cancer

A brief history of angiogenesis assays

Review | Published: 19 July 2011

Anca-Maria Cimpean*^,1, Domenico Ribatti² and Marius Raica¹

¹Department of Histology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania and ²Department of Human Anatomy and Histology, University of Bari Medical School, Italy

Abstract

The major problem with angiogenesis research is the choice of an appropriate assay. Currently, many in vitro and in vivo techniques are available for research into the functions of endothelial cells during angiogenesis. In this historical review article, we describe and evaluate the methodology and specific features of some of the most frequently used of these assays.

Keywords

angiogenesis assay, endothelial cell, in vtro model, in vivo model