Anca-Maria Cimpean*,1, Domenico Ribatti2 and Marius Raica1
1Department of Histology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania and 2Department of Human Anatomy and Histology, University of Bari Medical School, Italy
The major problem with angiogenesis research is the choice of an appropriate assay. Currently, many in vitro and in vivo techniques are available for research into the functions of endothelial cells during angiogenesis. In this historical review article, we describe and evaluate the methodology and specific features of some of the most frequently used of these assays.
angiogenesis assay, endothelial cell, in vtro model, in vivo model