Int. J. Dev. Biol. 65: 357 - 364 (2021)
Special Issue: Developmental Biology in Ibero-America - Part 2
Inducing your neighbors to become like you: cell recruitment in developmental patterning and growth
Published: 25 August 2020
Abstract
Cell differentiation, proliferation, and morphogenesis are generally driven by instructive signals that are sent and interpreted by adjacent tissues, a process known as induction. Cell recruitment is a particular case of induction in which differentiated cells produce a signal that drives adjacent cells to differentiate into the same type as the inducers. Once recruited, these new cells may become inducers to continue the recruitment process, closing a feed-forward loop that propagates the growth of a specific cell-type population. So far, little attention has been given to cell recruitment as a developmental mechanism. Here, we review the components of cell recruitment and discuss its contribution to development in three different examples: the Drosophila wing, the vertebrate inner ear, and the mammalian thyroid gland. Finally, we posit some open questions about the role of cell recruitment in organ patterning and growth.
Keywords
cell recruitment, patterning, growth, Drosophila wing, inner ear, thyroid