TY  - JOUR
TI  - Inducing your neighbors to become like you: cell recruitment in developmental patterning and growth
AU  - Muñoz-Nava, LuisM.
AU  - Flores-Flores, Marycruz
AU  - Nahmad, Marcos
T2  - The International Journal of Developmental Biology
AB  - Cell differentiation, proliferation, and morphogenesis are generally driven by instructive signals that are sent and interpreted by adjacent tissues, a process known as induction. Cell recruitment is a particular case of induction in which differentiated cells produce a signal that drives adjacent cells to differentiate into the same type as the inducers. Once recruited, these new cells may become inducers to continue the recruitment process, closing a feed-forward loop that propagates the growth of a specific cell-type population. So far, little attention has been given to cell recruitment as a developmental mechanism. Here, we review the components of cell recruitment and discuss its contribution to development in three different examples: the Drosophila wing, the vertebrate inner ear, and the mammalian thyroid gland. Finally, we posit some open questions about the role of cell recruitment in organ patterning and growth.
PY  - 2021
DO  - 10.1387/ijdb.200127mn
VL  - 65
IS  - 4-5-6
SP  - 357
EP  - 364
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/200127mn
Y2  - 2024/11/21/13:50:25
ER  -