The International Journal of Developmental Biology

Int. J. Dev. Biol. 64: 203 - 211 (2020)

Vol 64, Issue 1-2-3

Special Issue: Developmental Biology in India - First Part

Simultaneous differentiation of articular and transient cartilage: WNT-BMP interplay and its therapeutic implication

Published: 23 June 2020

Tathagata Biswas, Akrit P. Jaswal, Upendra S. Yadav and Amitabha Bandyopadhyay*

Indian Institute of Technology Kanpur, India


Limb skeleton forms through the process of endochondral ossification. This process of osteogenesis proceeds through an intermediate cartilage template and involves several stages of chondrocyte maturation and eventual bone formation. During the process of endochondral ossification, interplay between BMP and WNT signaling regulate simultaneous differentiation of articular and transient cartilage. In this review, we focus on the recent literature which explores the simultaneous differentiation of these two different types of cartilage. We discuss a new paradigm of developmental biology-inspired tissue engineering of bone and cartilage grafts and provide novel insight into treatment of osteoporosis.


endochondral ossification, articular cartilage, transient cartilage, BMP signaling, WNT signaling

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