The International Journal of Developmental Biology

Volume 56 > Issue 6-7-8 (Special Issue)

Cover Vol. 56 N. 6-7-8

The Hydra Model System

Edited by: Brigitte Galliot

Cover Legend

The freshwater polyp Hydra has been used to study regeneration and the development of animal form for more than 250 years. Accumulating evidence suggests that all three cell lineages composing the polyp's body act like stem cell systems. Therefore, Hydra has now started to attract interest in ancestral stem cell biology. In the gastric region of the illustrated polyp and its asexual bud, interstitial stem cells and proliferating nematocyte precursors show mRNA expression of the protooncogene and stem cell maintenance factor myc1 as visualized by in situ hybridization (blue color). For more details, see the paper by Hobmayer et al., pp 509-517.



The Hydra Model System

Brigitte Galliot

Int. J. Dev. Biol. (2012) 56: 407-409

The heuristic value of the Hydra model system

Hydra, a fruitful model system for 270 years

Brigitte Galliot

Int. J. Dev. Biol. (2012) 56: 411-423

The Trembley Effect or the birth of marine zoology

Marc J. Ratcliff

Int. J. Dev. Biol. (2012) 56: 425-436

The Hydra model - a model for what?

Alfred Gierer

Int. J. Dev. Biol. (2012) 56: 437-445

Adult Developmental Biology


Modeling pattern formation in hydra: a route to understanding essential steps in development

Hans Meinhardt

Int. J. Dev. Biol. (2012) 56: 447-462

Transplantation analysis of developmental mechanisms in Hydra

Hiroshi Shimizu

Int. J. Dev. Biol. (2012) 56: 463-472

The head organizer in Hydra

Hans R. Bode

Int. J. Dev. Biol. (2012) 56: 473-478

Hydra, the everlasting embryo, confronts aging

Daniel E. Martínez and Diane Bridge2

Int. J. Dev. Biol. (2012) 56: 479-487

Stem cell Biology

Interstitial stem cells in Hydra: multipotency and decision-making

Charles N. David

Int. J. Dev. Biol. (2012) 56: 489-497

Germline stem cells and sex determination in Hydra

Chiemi Nishimiya-Fujisawa and Satoru Kobayashi

Int. J. Dev. Biol. (2012) 56: 499-508

Stemness in Hydra - a current perspective

Bert Hobmayer, Marcell Jenewein, Dominik Eder, Marie-Kristin Eder, Stella Glasauer, Sabine Gufler, Markus Hartl and Willi Salvenmoser

Int. J. Dev. Biol. (2012) 56: 509-517

Hydractinia, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency

Günter Plickert, Uri Frank and Werner A. Müller

Int. J. Dev. Biol. (2012) 56: 519-534

Cell to tissue signaling

The Hydra genome: insights, puzzles and opportunities for Developmental Biologists

Robert E. Steele

Int. J. Dev. Biol. (2012) 56: 535-542

Peptide signaling in Hydra

Toshitaka Fujisawa and Eisuke Hayakawa

Int. J. Dev. Biol. (2012) 56: 543-550

Coordinated modulation of cellular signaling through ligand-gated ion channels in Hydra vulgaris (Cnidaria, Hydrozoa)

Paola Pierobon

Int. J. Dev. Biol. (2012) 56: 551-565

Components, structure, biogenesis and function of the Hydra extracellular matrix in regeneration, pattern formation and cell differentiation

Michael P. Sarras (Jr)

Int. J. Dev. Biol. (2012) 56: 567-576

The Nematocyst: a molecular map of the Cnidarian stinging organelle

Anna Beckmann and Suat Özbek

Int. J. Dev. Biol. (2012) 56: 577-582

Hydra, a model system to trace the emergence of boundaries in developing eumetazoans

Angelika Böttger and Monika Hassel

Int. J. Dev. Biol. (2012) 56: 583-591


Hydra, a versatile model to study the homeostatic and developmental functions of cell death

Silke Reiter, Marco Crescenzi, Brigitte Galliot and Wanda Buzgariu

Int. J. Dev. Biol. (2012) 56: 593-604

Ecotoxicology and environment

What Hydra can teach us about chemical ecology – how a simple, soft organism survives in a hostile aqueous environment

Tamar Rachamim and Daniel Sher

Int. J. Dev. Biol. (2012) 56: 605-611

Hydra, a model system for environmental studies

Brian Quinn, François Gagné, Christian Blaise

Int. J. Dev. Biol. (2012) 56: 613-625

Value of the Hydra model system for studying symbiosis

Goran Kovacevic

Int. J. Dev. Biol. (2012) 56: 627-635



How to use Hydra as a model system to teach biology in the classroom

Patricia Bossert and Brigitte Galliot

Int. J. Dev. Biol. (2012) 56: 637-652