Int. J. Dev. Biol. 60: 327 - 336 (2016)

https://doi.org/10.1387/ijdb.160420bk

Vol 60, Issue 10-11-12

Special Issue: Atlas of Human Experimental Teratomas

Honoring the work and life of Leroy C. Stevens. A symposium as part of the International Stem Cell Initiative Workshop

Published: 9 December 2016

Christopher F. Graham¹, Davor Solter², John D. Gearhart³, Joseph H. Nadeau⁴ and Barbara B. Knowles*^,5

¹Zoology Department, Oxford University, U.K. ²Emeritus, Max Planck Society, Germany, ³University of Pennsylvania, Philadelphia, PA, USA, ⁴Pacific Northwest Research Institute, Seattle, WA, USA and ⁵Emerita, The Jackson Laboratory, Bar Harbor, ME, USA

Abstract

In 2016, a symposium was convened in Leroy C. Stevens’ honor, in association with a meeting of the International Stem Cell Initiative (ISCI). ISCI, funded internationally, is composed of a group of ~100 scientists from many countries, under the leadership of Peter Andrews, who have worked together to characterize a significant number of human pluripotent stem cell lines, to monitor their genetic stability and their differentiation into mature cell types and tissues in vitro and in vivo. Those at the ISCI meeting puzzled through one of the thorniest problems in the therapeutic use of the differentiated derivatives of pluripotent stem cells for human therapy; namely, pluripotent stem cells can differentiate into any cell type in the adult organism, but they also have the capacity for unlimited self-renewal, hence if mutated they may have tumorigenic potential. The meeting considered how these cells might become genetically or epigenetically abnormal and how the safety of these cells for human therapeutic uses could be assessed and assured. The symposium was an opportunity to pay tribute to Leroy Stevens and to the basic science origins of this newest aspect of regenerative medicine. It was a time to reflect on the past and on how it can influence the future of our field.

Keywords

Leroy C. Stevens, stem cell, PSC, human therapy, tumor