The International Journal of Developmental Biology

Volume 60 > Issue 10-11-12 (Special Issue)

Cover Vol. 60 N. 10-11-12

Atlas of Human Experimental Teratomas

Edited by: Ivan Damjanov and Peter W. Andrews

Cover Legend

The teratoma essay has become the “gold standard” pluripotency test for stem cell lines. It involves the xenografting of human pluripotent stem cells (hPSC) into immunosuppressed mice in order to determine if they can produce teratomas containing derivatives of all the three embryonic germ layers. Xenografted hPSC may also recapitulate certain aspects of early embryonic development and form embryoid bodies and extra-embryonic tissues, such as yolk sac. In these cover images, we show representative differentiation patterns seen in human experimental teratomas. In the upper row, from the left, yolk sac elements, an embryoid body and several neural rosettes are shown. Below, examples of endoderm and mesoderm differentiation can be seen, together with a recipient immunosuppressed mouse. For more information, see article by Ivan Damjanov and Peter Andrews, pp. 337-419, in this issue. Mouse photo kindly reproduced with generous permission from the "Animal Resources Centre", Western Australia (


Pluripotent human stem cells: Standing on the shoulders of giants

Ivan Damjanov and Peter W Andrews

Int. J. Dev. Biol. (2016) 60: 321-325

Symposium Report

Honoring the work and life of Leroy C. Stevens. A symposium as part of the International Stem Cell Initiative Workshop

Christopher F. Graham, Davor Solter, John D. Gearhart, Joseph H. Nadeau and Barbara B. Knowles

Int. J. Dev. Biol. (2016) 60: 327-336

Atlas of Human Experimental Teratomas


Teratomas produced from human pluripotent stem cells xenografted into immunodeficient mice - a histopathology atlas

Ivan Damjanov and Peter W. Andrews

Int. J. Dev. Biol. (2016) 60: 337-419