The International Journal of Developmental Biology

Int. J. Dev. Biol. 59: 187 - 194 (2015)

Vol 59, Issue 4-5-6

Gliolectin positively regulates Notch signalling during wing-vein specification in Drosophila

Published: 15 October 2015

Naveen Prasad* and Lingadahalli S. Shashidhara

Indian Institute of Science Education and Research (IISER), Pune, India


Notch signalling is essential for animal development. It integrates multiple pathways controlling cell fate and specification. Here we report the genetic characterization of Gliolectin, presumably a lectin, a cytoplasmic protein, significantly enriched in Golgi bodies. Its expression overlaps with regions where Notch is activated. Loss of gliolectin function results in ectopic veins, while gain of its function causes loss of wing veins. It positively regulates Enhancer of split mβ, a target of Notch signalling. These observations suggest that it is a positive regulator of Notch signalling during wing development in Drosophila.


Glec, Notch, wing vein development, D/V boundary

Full text in web format is not available for this article. Please download the PDF version.