The International Journal of Developmental Biology

Int. J. Dev. Biol. 54: 1107 - 1115 (2010)

Vol 54, Issue 6-7

Special Issue: Developmental Hematopoiesis

Transcription factor interplay during Drosophila haematopoiesis

Published: 17 July 2010

Lucas Waltzer*, Vanessa Gobert, Dani Osman and Marc Haenlin*

Centre de Biologie du Développement, CNRS, Université de Toulouse, Toulouse, France


Transcription factors play a key role in regulating blood cell fate choice and differentiation. In this review, we examine current knowledge of the function and mode of action of the transcription factors implicated in haematopoiesis in Drosophila. We particularly emphasize regulation by transcription factors and cofactors, such as GATA, FOG and RUNX, whose homologues in mammals also control blood cell formation and we discuss the cross talks between these transcriptional regulators at the different stages of haematopoietic cell fate decision.


Drosophila, haematopoiesis, transcription

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