Int. J. Dev. Biol. 52: 1051 - 1057 (2008)
Masculinization of XX Drosophila transgenic flies expressing the Ceratitis capitata DoublesexM isoform
Original Article | Published: 1 October 2008
Abstract
The Doublesex (DSX) transcription factor regulates somatic sexual differentiation in Drosophila melanogaster. Female and male isoforms (DSXF and DSXM) are produced due to sex-specific RNA splicing. Here we show that in the distantly related dipteran Ceratitis capitata, the DSXM male-specific isoform is conserved and able to induce masculinization of both somatic and germline tissues when ectopically expressed in XX Drosophila transgenic individuals.
Keywords
Ceratitis, sex determination, DSXM isoform