The International Journal of Developmental Biology

Int. J. Dev. Biol. 52: 999 - 1004 (2008)

Vol 52, Issue 7

Cloning and developmental expression of the soxB2 genes, sox14 and sox21, during Xenopus laevis embryogenesis

Published: 1 September 2008

Doreen D. Cunningham, Zhuo Meng, Bernd Fritzsch1 and Elena Silva Casey*

Georgetown University, Department of Biology, Washington DC and 1Creighton University, Department of Biomedical Sciences, Omaha, NE, USA


The Sox family of transcription factors is thought to regulate gene expression in a wide variety of developmental processes. Here we describe the cloning of the X. laevis orthologs of the SoxB2 family of transcription factors, sox14 and sox21. In situ hybridization revealed that sox14 expression is restricted to the hypothalamus, dorsal thalamus, the optic tectum, a region of the somatic motornucleus in the midbrain and hindbrain, the vestibular nuclei in the hindbrain and a discrete ventral domain in the developing spinal cord. In contrast to the limited expression domain of sox14, sox21 is found throughout the developing central nervous system, including the olfactory placodes, with strongest expression at the boundary between the midbrain and hindbrain.


Sox, neurogenesis, Xenopus, neural tube

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