The International Journal of Developmental Biology

Int. J. Dev. Biol. 63: 573 - 578 (2019)

Vol 63, Issue 11-12

Brinster Spermatogonial Stem Cell Transplantation 25th Anniversary Symposium

Meeting Report | Published: 27 February 2020

Ina Dobrinski*,1 and Kyle Orwig2

1Dept. of Comparative Biology & Experimental Medicine, University of Calgary, Calgary, AB, Canada and and 2Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA


The Symposium, co-sponsored by the Institute of Regenerative Medicine, the University Research Foundation, the Center for Research on Reproduction and Women’s Health, the Penn Center for the Study of Epigenetics in Reproduction, and Penn Vet at the University of Pennsylvania, commemorated the 25th anniversary of the first publications describing spermatogonial stem cell (SSC) transplantation in mice. This transformative approach has propelled advances in our understanding of germ cell biology, has been translated to a variety of vertebrate species, and holds translational potential for fertility restoration in patients. The symposium opened with a lecture by Dr. Brinster reflecting on the origin of the work, as well as advances over the 25 years up to present ongoing studies. Following Dr. Brinster’s remarks, 10 lectures were presented by distinguished scientists, including several of Dr. Brinster’s former trainees and colleagues. The symposium closed with a keynote lecture by Dr. David Page. Topics ranged from aspects of basic SSC biology to applications in large animal models and potential translation to treating human male infertility. Many of the studies presented directly resulted from SSC transplantation technology highlighting its tremendous impact in advancing the field. The Symposium program and the lectures can be found at


spermatogonial stem cell, transplantation, animal model, fertility preservation

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