Int. J. Dev. Biol. 62: 49 - 55 (2018)
Special Issue: The Chick Embryo Model System
Contributions of the chick embryo and experimental embryology to understanding the cellular mechanisms of neurulation
Published: 14 March 2018
Abstract
The chick embryo has served as a workhorse for experimental embryological studies designed to elucidate mechanisms underlying neurulation, the process that forms the neural tube, the rudiment of the entire adult central nervous system. Early chick embryos developing in whole-embryo culture can be readily manipulated in cut-and-paste-type experiments, and this attribute makes this model system unparalleled for studying the morphogenesis of embryos and their organ rudiments. How the chick embryo and experimental embryology have contributed to our understanding of critical events of neurulation are summarized.
Keywords
cell-shape, convergent-extension, ectoderm, microfilament, microtubule, neural plate, oriented mitosis