The International Journal of Developmental Biology

Int. J. Dev. Biol. 54: 1597 - 1607 (2010)

Vol 54, Issue 11-12

Special Issue: Animal Cloning & Cell Reprogramming

Virus, development and pluripotent stem cells - an interview with Rudolf Jaenisch

Interview | Published: 23 February 2011

José B. Cibelli*

Cellular Reprogramming Laboratory, Michigan State University, Michigan, USA


Rudolf Jaenisch explains how the quest for an answer to the simple question of viral tropism in the mouse lead him to a life-long career in regulation of gene expression in the early embryo and pluripotent stem cells. He shares his experience about what it takes to develop into a successful scientist; expresses his concern about the challenges facing young scientists entering the field – not all of them funding related - and candidly offers some solid tips on opportunities to take advantage of and mistakes to avoid. Being mindful of when to let go of a project, and staying focused on what is important, are probably obvious tips, but they need to be re-stated, since they also appear to be the most difficult to accomplish. Dr. Jaenisch continues to work tirelessly on the problem of epigenetic control in the early embryo and its connection with stem cells.


Jaenisch, viral tropism, success pluripotent stem cell, epigenetics

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