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The International Journal of Developmental Biology

Volume 63 > Issue 6-7

Cover Vol. 63 N. 6-7

Cover Legend

In this issue, Sosa et al. used bisected Xenopus laevis embryos to analyze genome-wide transcriptional regulation during twinning. The center image shows a normal tailbud whole embryo, which displays a dorsal crescent (D) and a more pigmented ventral (V) region at midblastula. In the left and right sagittal half embryos identical twins are generated. Note that the distribution of maternal pigment is asymmetric due to a 90° rotation of the Spemann-Mangold organizer center in these identical twins. Dorsal half embryos scale to form a well-patterned embryo, whereas ventral half embryos lack a dorsal axis and consist of only ventral tissues with a large coelomic cavity. The data presented represents a treasure trove of gene regulation events during early embryo regeneration. For further information, see Sosa et al., pp. 301-309.

Original Articles

Apoptosis in Hydra: function of HyBcl-2 like 4 and proteins of the transmembrane BAX inhibitor motif (TMBIM) containing family

Mina Motamedi, Laura Lindenthal, Anita Wagner, Margherita Kemper, Jasmin Moneer, Mona Steichele, Alexander Klimovich, Jörg Wittlieb, Marcell Jenewein and Angelika Böttger

Int. J. Dev. Biol. (2019) 63: 259-270

https://doi.org/10.1387/ijdb.180199ab

OPEN ACCESS

Definitive endoderm differentiation is promoted in suspension cultured human iPS-derived spheroids more than in adherent cells

Shigeharu G. Yabe, Junko Nishida, Satsuki Fukuda, Fujie Takeda, Kiyoko Nashiro, Masato Ibuki and Hitoshi Okochi

Int. J. Dev. Biol. (2019) 63: 271-280

https://doi.org/10.1387/ijdb.180251sy

Technical Articles

Advanced microinjection protocol for gene manipulation using the model newt Pleurodeles waltl

Toshinori Hayashi, Mie Nakajima, Mitsuki Kyakuno, Kanako Doi, Ikumi Manabe, Shouhei Azuma and Takashi Takeuchi

Int. J. Dev. Biol. (2019) 63: 281-286

https://doi.org/10.1387/ijdb.180297th

Use of soluble sperm extract to improve cloning efficiency in zebrafish

Sukumal Prukudom, Gloria I. Perez, Jose B. Cibelli and Kannika Siripattarapravat

Int. J. Dev. Biol. (2019) 63: 287-293

https://doi.org/10.1387/ijdb.180367ks

Isolation and phenotyping of potential stem cells from the umbilical cord of the bottlenose dolphin(Tursiops truncatus)

Annalaura Mancia, Giulia Zuccon, Denise Lunardi, Barbara Biancani, Claudia Gili, Roscoe Stanyon, Daniel García-Parraga, Mara Mellado, Luigi Abelli and Victoria Moreno-Manzano

Int. J. Dev. Biol. (2019) 63: 295-299

https://doi.org/10.1387/ijdb.190042am

Developmental Expression Pattern

OPEN ACCESS

Transcriptome analysis of regeneration during Xenopus laevis experimental twinning

Eric A. Sosa, Yuki Moriyama, Yi Ding, Nydia Tejeda-Muñoz, Gabriele Colozza and Edward M. De Robertis

Int. J. Dev. Biol. (2019) 63: 301-309

https://doi.org/10.1387/ijdb.190006ed

Comparative analysis of p4ha1 and p4ha2 expression during Xenopus laevis development

Davide Martini, Martina Giannaccini, Viviana Guadagni, Silvia Marracci, Guido Giudetti and Massimiliano Andreazzoli

Int. J. Dev. Biol. (2019) 63: 311-316

https://doi.org/10.1387/ijdb.190067ma