The International Journal of Developmental Biology

Volume 56 > Issue 10-11-12 (Special Issue)

Cover Vol. 56 N. 10-11-12

Female Germ Cells in Development & Tumors

Edited by: Maurizio Zuccotti, Carlo A. Redi and Silvia Garagna

Cover Legend

La Folie des Grandeurs [Megalomania or Delusions of Grandeur] (1962) painted by the Belgian surrealist René F.G. Magritte (1898-1967), is suggestive of the theory of ovist preformationism which held that unborn offspring existed fully formed in the eggs of its mother prior to conception. This idea was heralded by Antonio Vallisnieri (1661-1730), who even believed that in the ovary of the first woman, the entire human race in miniature was present from the beginning. In addition, Magritte’s painting is also reminiscent of the phenomenon of parthenogenesis, embryo development from an unfertilized egg, which is the biopathological origin of ovarian teratoma tumors. Oil on canvas. 100.4 x 81.3 cm. Access # 78-145 E. Photographer: Hickey-Robertson, Houston, TX, USA. Reproduced with kind permission from The Menil Collection, Houston TX, USA.


Study an egg today to make an embryo tomorrow

Maurizio Zuccotti, Carlo Alberto Redi and Silvia Garagna

Int. J. Dev. Biol. (2012) 56: 761-764

Female germ cells in development

Over 40 years of mentoring, educating, and researching in the world of oocytes

Catherine M.H. Combelles and David Albertini

Int. J. Dev. Biol. (2012) 56: 765-770

From primordial germ cells to oocytes

The migration and loss of human primordial germ stem cells from the hind gut epithelium towards the gonadal ridge

Linn Salto Mamsen, Christian Beltoft Brøchner, Anne Grete Byskov and Kjeld Møllgard

Int. J. Dev. Biol. (2012) 56: 771-778

Regulation of germ cell meiosis in the fetal ovary

Cassy M. Spiller, Josephine Bowles and Peter Koopman

Int. J. Dev. Biol. (2012) 56: 779-787

Comparative molecular portraits of human unfertilized oocytes and primordial germ cells at 10 weeks of gestation

Ferdinand Diedrichs, Barbara Mlody, Peggy Matz, Heiko Fuchs, Lukas Chavez, Katharina Drewsand James Adjaye

Int. J. Dev. Biol. (2012) 56: 789-797


Metabolism throughout follicle and oocyte development in mammals

Esther Collado-Fernandez, Helen M. Picton and Rémi Dumollard

Int. J. Dev. Biol. (2012) 56: 799-808

The role of Akt signalling in the mammalian ovary

Sandra Cecconi, Annunziata Mauro, Valerio Cellini and Felice Patacchiola

Int. J. Dev. Biol. (2012) 56: 809-817

The antral follicle: a microenvironment for oocyte differentiation

Margo L. Hennet and Catherine M. H. Combelles

Int. J. Dev. Biol. (2012) 56: 819-831

Influence of the zona pellucida of the mouse egg on folliculogenesis and fertility

Paul M. Wassarman and Eveline S. Litscher

Int. J. Dev. Biol. (2012) 56: 833-839

Oocyte ageing and its cellular basis

Ursula Eichenlaub-Ritter

Int. J. Dev. Biol. (2012) 56: 841-852

Genetic and epigenetic signatures

OCT4 and the acquisition of oocyte developmental competence during folliculogenesis

Maurizio Zuccotti, Valeria Merico, Martina Belli, Francesca Mulas, Lucia Sacchi, Blaz Zupan, Carlo Alberto Redi, Alessandro Prigione, James Adjaye, Riccardo Bellazzi and Silvia Garagna

Int. J. Dev. Biol. (2012) 56: 853-858

Knowledge-based bioinformatics for the study of mammalian oocytes

Francesca Mulas, Lucia Sacchi, Lan Zagar, Silvia Garagna, Maurizio Zuccotti, Blaz Zupan and Riccardo Bellazzi

Int. J. Dev. Biol. (2012) 56: 859-866


DNA methylation establishment during oocyte growth: mechanisms and significance

Shin-Ichi Tomizawa, Joanna Nowacka-Woszuk and Gavin Kelsey

Int. J. Dev. Biol. (2012) 56: 867-875

Genome organization and epigenetic marks in mouse germinal vesicle oocytes

Amelie Bonnet-Garnier, Prisca Feuerstein, Martine Chebrout, Renaud Fleurot, Habib-Ullah Jan, Pascale Debey and Nathalie Beaujean

Int. J. Dev. Biol. (2012) 56: 877-887

Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte

Feikun Yang, Claudia Baumann, Maria M. Viveiros and Rabindranath De La Fuente

Int. J. Dev. Biol. (2012) 56: 889-899

In vitro growth of the ovarian follicle

Strategies to support human oocyte development in vitro

Evelyn E. Telfer and Marie McLaughlin

Int. J. Dev. Biol. (2012) 56: 901-907

Human oocyte maturation in vitro

Giovanni Coticchio, Mariabeatrice Dal-Canto, Maria-Cristina Guglielmo, Mario Mignini-Renzini and Rubens Fadini

Int. J. Dev. Biol. (2012) 56: 909-918

The use of immature oocytes in the fertility preservation of cancer patients: current promises and challenges

Catherine M. H. Combelles and Gabriela Chateau

Int. J. Dev. Biol. (2012) 56: 919-929

Towards a 3D culture of mouse ovarian follicles

Martina Belli, Giulia Vigone, Valeria Merico, Carlo Alberto Redi, Maurizio Zuccotti and Silvia Garagna

Int. J. Dev. Biol. (2012) 56: 931-937

Female germ cells in tumors


Above the borderland between normal and neoplastic development

Juan Aréchaga and Ivan Damjanov

Int. J. Dev. Biol. (2012) 56: 939-948

The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers

Janet L. Pitman, Alan S. McNeilly, Judy R. McNeilly, Laura E. Hays, Grover C. Bagby Jr., Heywood R. Sawyer and Kenneth P. McNatty

Int. J. Dev. Biol. (2012) 56: 949-958

Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer

Joëlle Dupont, Maxime Reverchon, Lucie Cloix, Pascal Froment and Christelle Ramé

Int. J. Dev. Biol. (2012) 56: 959-967

Gliomatosis peritonei as a natural experiment in tissue differentiation

Francisco F. Nogales, Ovidiu Preda and Isabel Dulcey

Int. J. Dev. Biol. (2012) 56: 969-974

Oocyte nuclear transfers


Amphibian interorder nuclear transfer embryos reveal conserved embryonic gene transcription, but deficient DNA replication or chromosome segregation

Patrick Narbonne and John B. Gurdon

Int. J. Dev. Biol. (2012) 56: 975-986