The International Journal of Developmental Biology

Volume 56 > Issue 1-2-3 (Special Issue)

Cover Vol. 56 N. 1-2-3

The Planaria Model System

Edited by: Emili Saló and Kiyokazu Agata

Cover Legend

The spectacular regeneration capability of soft-bodied planarians has enchanted us for many years. Within days of losing its head and tail, a new head and a new tail are formed. The new tissues, although not yet pigmented (see unpigmented extremes of the illustrated planarian), are perfectly patterned, and perfectly functional. One of the “secrets” of how planarians achieve this is a population of totipotent stem cells called neoblasts. The curious reader is invited, by exploring the papers in this Special Issue, to find out if planarians really have discovered the secret of immortality, living in the incessant fountain of youth, … or not! The illustrated planarian belongs to the species Schmidtea mediterranea, and it is a freshwater planarian. For more details, see paper by Galloni, pp. 103-116.



Planarian regeneration: a classic topic claiming new attention

Emili Saló and Kiyokazu Agata

Int. J. Dev. Biol. (2012) 56: 1-4

Introductory Papers

Evolutionary history of the Tricladida and the Platyhelminthes: an up-to-date phylogenetic and systematic account

Marta Riutort, Marta Álvarez-Presas, Eva Lázaro, Eduard Solà and Jordi Paps

Int. J. Dev. Biol. (2012) 56: 5-17

The planarian neoblast: the rambling history of its origin and some current black boxes

Jaume Baguñà

Int. J. Dev. Biol. (2012) 56: 19-37

Planarian embryology in the era of comparative developmental biology

José M. Martín-Durán, Francisco Monjo and Rafael Romero

Int. J. Dev. Biol. (2012) 56: 39-48

The past and present of planarians - An interview with Vittorio Gremigni

Alessandra Salvetti and Leonardo Rossi

Int. J. Dev. Biol. (2012) 56: 49-52


Wnt signaling in planarians: new answers to old questions

Maria Almuedo-Castillo, Miquel Sureda-Gómez and Teresa Adell

Int. J. Dev. Biol. (2012) 56: 53-65

Small RNA pathways in Schmidtea mediterranea

Alissa M. Resch and Dasaradhi Palakodeti

Int. J. Dev. Biol. (2012) 56: 67-74


An insulin-like peptide regulates size and adult stem cells in planarians

Claire M. Miller and Phillip A. Newmark

Int. J. Dev. Biol. (2012) 56: 75-82

Decreased neoblast progeny and increased cell death during starvation-induced planarian degrowth

Cristina González-Estévez, Daniel A. Felix, Gustavo Rodríguez-Esteban and A. Aziz Aboobaker

Int. J. Dev. Biol. (2012) 56: 83-91

Comprehensive gene expression analyses in pluripotent stem cells of a planarian, Dugesia japonica

Norito Shibata, Tetsutaro Hayashi, Ryutaro Fukumura, Junsuke Fujii, Tomomi Kudome-Takamatsu, Osamu Nishimura, Syozo Sano, Fuyan Son, Nobuko Suzuki, Ryoko Araki, Masumi Abe and Kiyokazu Agata

Int. J. Dev. Biol. (2012) 56: 93-102

Global irradiation effects, stem cell genes and rare transcripts in the planarian transcriptome

Mireille Galloni

Int. J. Dev. Biol. (2012) 56: 103-116

Heterogeneity of planarian stem cells in the S/G2/M phase

Sören Moritz, Franziska Stöckle, Claudia Ortmeier, Henning Schmitz, Gustavo Rodríguez-Esteban, Göran Key and Luca Gentile

Int. J. Dev. Biol. (2012) 56: 117-125

Stem cell protection mechanisms in planarians: the role of some heat shock genes

Maria-Emilia Isolani, Maria Conte, Paolo Deri and Renata Batistoni

Int. J. Dev. Biol. (2012) 56: 127-133

Stem cells and neural signalling: the case of neoblast recruitment and plasticity in low dose X-ray treated planarians

Leonardo Rossi, Paola Iacopetti and Alessandra Salvetti

Int. J. Dev. Biol. (2012) 56: 135-142

Regeneration of neuronal cell types in Schmidtea mediterranea: an immunohistochemical and expression study

Susanna Fraguas, Sara Barberán, Begoña Ibarra, Linda Stöger and Francesc Cebrià

Int. J. Dev. Biol. (2012) 56: 143-153

Inhibitory Smads and bone morphogenetic protein (BMP) modulate anterior photoreceptor cell number during planarian eye regeneration

Alejandro González-Sastre, Mª Dolores Molina and Emili Saló

Int. J. Dev. Biol. (2012) 56: 155-163

The Dr-nanos gene is essential for germ cell specification in the planarian Dugesia ryukyuensis

Haruka Nakagawa, Hirotsugu Ishizu, Ayako Chinone,Kazuya Kobayashi and Midori Matsumoto

Int. J. Dev. Biol. (2012) 56: 165-171

The planarian P2X homolog in the regulation of asexual reproduction

Toshihide Sakurai, Hayoung Lee, Makoto Kashima, Yumi Saito, Tetsutaro Hayashi, Tomomi Kudome-Takamatsu, Osamu Nishimura, Kiyokazu Agata and Norito Shibata

Int. J. Dev. Biol. (2012) 56: 173-182

Physiological and molecular characterisation of cadmium stress in Schmidtea mediterranea

Michelle Plusquin, An-Sofie Stevens, Frank Van Belleghem, Olivier Degheselle, Andromeda Van Roten, Jessica Vroonen, Ronny Blust, Ann Cuypers, Tom Artois and Karen Smeets

Int. J. Dev. Biol. (2012) 56: 183-191

Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina

Oné R. Pagán, Debra Baker, Sean Deats, Erica Montgomery, Matthew Tenaglia, Clinita Randolph, Dharini Kotturu, Christopher Tallarida, Daniel Bach, Galia Wilk, Scott Rawls and Robert B. Raffa

Int. J. Dev. Biol. (2012) 56: 193-196