The International Journal of Developmental Biology

Volume 55 > Issue 7-8-9 (Special Issue)

Cover Vol. 55 N. 7-8-9

Mammary Gland in Development & Cancer

Edited by: Marc Bracke and Olivier De Wever

Cover Legend

She Lives Breast Cancer Awareness by Shelley Bain promotes breast cancer awareness and honors all women who have battled breast cancer. Shelley is a self-taught artist, who lives and works in Rockville, Maryland (USA). Through her Art, she celebrates women and the wonder that women bring to the world, by communicating her view of the amazing world of femininity, female power and the sense of pride of women. Her art expresses many aspects of the female form, from the beauty in all women, to the pain and suffering, as well as the joys and power of being a woman. Reproduced with kind permission from S. Bain. Shelley’s Art can be viewed at:



Developmental and cancer research on the mammary gland nowadays

Marc Bracke and Olivier De Wever

Int. J. Dev. Biol. (2011) 55: 667-669

Introductory Papers

Ecosystems of invasion and metastasis in mammary morphogenesis and cancer

Marc Mareel and Susana Constantino

Int. J. Dev. Biol. (2011) 55: 671-684

The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology

Suzanne A. Eccles

Int. J. Dev. Biol. (2011) 55: 685-696

From the laboratory to the patient and back - an interview with Marc Mareel

Marc E. Bracke

Int. J. Dev. Biol. (2011) 55: 697-702

Four decades of discovery in breast cancer research and treatment – an interview with V. Craig Jordan

Marc Poirot

Int. J. Dev. Biol. (2011) 55: 703-712

Signaling networks in cancer - an interview with Christian Gespach

Olivier De Wever

Int. J. Dev. Biol. (2011) 55: 713-718

Mammary gland development

Mammary gland stem cells: current status and future challenges

Agla J.R. Fridriksdottir, Ole W. Petersen and Lone Rønnov-Jessen

Int. J. Dev. Biol. (2011) 55: 719-729

c-Jun N-terminal kinase activity supports multiple phases of 3D-mammary epithelial acinus formation

Sara McNally, Emmett McArdle, Emer Gilligan, Silvia Napoletano, Malgorzata Gajewska, Orla Bergin, Sarah McCarthy, Jacqueline Whyte, Alessandro Bianchi, Julianne Stack and Finian Martin

Int. J. Dev. Biol. (2011) 55: 731-744


Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland

Jenean O’Brien, Kirk Hansen, Dalit Barkan, Jeffrey Green and Pepper Schedin

Int. J. Dev. Biol. (2011) 55: 745-755

Remodeling mechanisms of the mammary gland during involution

Christine J. Watson and Peter A. Kreuzaler

Int. J. Dev. Biol. (2011) 55: 757-762

The mammary myoepithelial cell

Mejdi Moumen, Aurélie Chiche, Stéphanie Cagnet, Valérie Petit, Karine Raymond, Marisa M. Faraldo, Marie-Ange Deugnier and Marina A. Glukhova

Int. J. Dev. Biol. (2011) 55: 763-771

Connexins: a junctional crossroad to breast cancer

Jamal A. El-Saghir, Elia T. El-Habre, Marwan E. El-Sabban and Rabih S. Talhouk,2

Int. J. Dev. Biol. (2011) 55: 773-780

Insulin-like growth factor binding proteins and mammary gland development

Angara Sureshbabu, Elizabeth Tonner and David J. Flint

Int. J. Dev. Biol. (2011) 55: 781-789

The mammary cancer phenotype

Canine mammary tumors contain cancer stem-like cells and form spheroids with an embryonic stem cell signature

Maria Ferletta, Jan Grawé and Eva Hellmén

Int. J. Dev. Biol. (2011) 55: 791-799

Proteome changes induced by overexpression of the p75 neurotrophin receptor (p75NTR) in breast cancer cells

Jean-Philippe Wilmet, Christophe Tastet, Emilie Desruelles, Nathalie Ziental-Gelus, Vincent Blanckaert, Hubert Hondermarck and Xuefen Le Bourhis

Int. J. Dev. Biol. (2011) 55: 801-809

Cell adhesion and motility in mammary cancer

P-cadherin role in normal breast development and cancer

André Albergaria, Ana-Sofia Ribeiro, André-Filipe Vieira, Bárbara Sousa, Ana-Rita Nobre, Raquel Seruca, Fernando Schmitt and Joana Paredes

Int. J. Dev. Biol. (2011) 55: 811-822

Sialylation regulates galectin-3/ligand interplay during mammary tumour progression - a case of targeted uncloaking

Joana-Tavares de Oliveira, Augusto-José de Matos, Ana L. Santos, Rita Pinto, Joana Gomes, Venceslau Hespanhol, Roger Chammas, Aki Manninen, Emerson S. Bernardes, Celso Albuquerque Reis, Gerard Rutteman and Fátima Gärtner

Int. J. Dev. Biol. (2011) 55: 823-834

The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells

Lara Derycke, Christophe Stove, Anne-Sophie Vercoutter-Edouart, Olivier De Wever, Laurent Dollé, Nathalie Colpaert, Herman Depypere, Jean-Claude Michalski and Marc Bracke,1

Int. J. Dev. Biol. (2011) 55: 835-840

Paracrine and endocrine regulation of mammary cancer

Role of cancer-associated fibroblasts in breast cancer development and prognosis

Abdelilah Aboussekhra

Int. J. Dev. Biol. (2011) 55: 841-849


Adipocyte is a non-trivial, dynamic partner of breast cancer cells

Jinxiang Tan, Emilie Buache, Marie-Pierre Chenard, Nassim Dali-Youcef, Marie-Christine Rio

Int. J. Dev. Biol. (2011) 55: 851-859

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions

Damya Laoui, Kiavash Movahedi, Eva Van Overmeire, Jan Van den Bossche, Elio Schouppe, Camille Mommer, Alexandros Nikolaou, Yannick Morias, Patrick De Baetselier and Jo A. Van Ginderachter

Int. J. Dev. Biol. (2011) 55: 861-867

Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis

Vassiliki Pelekanou and Guy Leclercq

Int. J. Dev. Biol. (2011) 55: 869-878

Mammary cancer metastasis

Exosome signaling in mammary gland development and cancer

An Hendrix and Alistair N. Hume

Int. J. Dev. Biol. (2011) 55: 879-887

The tumor macroenvironment and systemic regulation of breast cancer progression

Zafira Castaño, Kristin Tracy and Sandra S. McAllister

Int. J. Dev. Biol. (2011) 55: 889-897