The International Journal of Developmental Biology

Volume 46 > Issue 7 (Special Issue)

Cover Vol. 46 N. 7

Limb Development

Edited by: Juan Hurlé and Juan C. Izpisúa-Belmonte

Cover Legend

Central motif of a magic realist painting portraying animate, isolated limbs as individuals. This picture entitled "Intermission" (1928) was painted by the Belgian surrealist René Magritte (1898-1967). Oil on canvas. Private collection.

Introductory papers

Developmental basis of limb evolution.

J Richard Hinchliffe

Int. J. Dev. Biol. (2002) 46: 835-845

The early history of the polarizing region: from classical embryology to molecular biology.

Cheryll Tickle

Int. J. Dev. Biol. (2002) 46: 847-852

How serendipity shaped a life; an interview with John W. Saunders.

John F. Fallon

Int. J. Dev. Biol. (2002) 46: 853-861

Positional information in vertebrate limb development; an interview with Lewis Wolpert.

Cheryll Tickle

Int. J. Dev. Biol. (2002) 46: 863-867


The progress zone model for specifying positional information.

Lewis Wolpert

Int. J. Dev. Biol. (2002) 46: 869-870

Programmed cell death in the developing limb.

Vanessa Zuzarte-Luís and Juan M Hurlé

Int. J. Dev. Biol. (2002) 46: 871-876

Interplay between the molecular signals that control vertebrate limb development.

Lee Niswander

Int. J. Dev. Biol. (2002) 46: 877-881

Retinoic acid and limb regeneration--a personal view.

Malcolm Maden

Int. J. Dev. Biol. (2002) 46: 883-886

Vertebrate limb regeneration and the origin of limb stem cells.

Susan V Bryant, Tetsuya Endo and David M Gardiner

Int. J. Dev. Biol. (2002) 46: 887-896

Cell adhesiveness and affinity for limb pattern formation.

Hiroshi Yajima, Kenji Hara, Hiroyuki Ide and Koji Tamura

Int. J. Dev. Biol. (2002) 46: 897-904

Limb muscle development.

Bodo Christ and Beate Brand-Saberi

Int. J. Dev. Biol. (2002) 46: 905-914

Signals regulating muscle formation in the limb during embryonic development.

Delphine Duprez

Int. J. Dev. Biol. (2002) 46: 915-925

Wnt signalling during limb development.

Vicki L Church and Philippa Francis-West

Int. J. Dev. Biol. (2002) 46: 927-936

Interactions between dorsal-ventral patterning genes lmx1b, engrailed-1 and wnt-7a in the vertebrate limb.

Haixu Chen and Randy L Johnson

Int. J. Dev. Biol. (2002) 46: 937-941

Bmp, Fgf and Wnt signalling in programmed cell death and chondrogenesis during vertebrate limb development: the role of Dickkopf-1.

Lars Grotewold and Ulrich Rüther

Int. J. Dev. Biol. (2002) 46: 943-947

Exogenous retinoic acid induces a stage-specific, transient and progressive extension of Sonic hedgehog expression across the pectoral fin bud of zebrafish.

Lisa Hoffman, Jennifer Miles, Fabien Avaron, Lynda Laforest and Marie-Andrée Akimenko

Int. J. Dev. Biol. (2002) 46: 949-956

Distribution and possible function of an adrenomedullin-like peptide in the developing chick limb bud.

M Reza Seghatoleslami, Alfredo Martínez, Frank Cuttitta and Robert A Kosher

Int. J. Dev. Biol. (2002) 46: 957-961

Identification of cis-elements regulating expression of Fgf10 during limb development.

Hidemi Sasak, Takashi Yamaoka, Hideyo Ohuchi, Akihiro Yasue, Tsutomu Nohno, Hirotaka Kawano, Shigeaki Kato, Mitsuo Itakura, Masaru Nagayama and Sumihare Noji

Int. J. Dev. Biol. (2002) 46: 963-967

Unusual pattern of Sonic hedgehog expression in the polydactylous mouse mutant Hemimelic extra-toes.

Isabelle Blanc, Antoine Bach and Benoît Robert

Int. J. Dev. Biol. (2002) 46: 969-974

The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud.

Yukari Yada, Shigeru Makino, Sadao Chigusa-Ishiwa and Toshihiko Shiroishi

Int. J. Dev. Biol. (2002) 46: 975-982

Human limb malformations; an approach to the molecular basis of development.

Karl-Heinz Grzeschik

Int. J. Dev. Biol. (2002) 46: 983-991