The International Journal of Developmental Biology

Volume 45 > Issue 1 (Special Issue)

Cover Vol. 45 N. 1

The Spemann-Mangold Organizer

Edited by: Eddy DeRobertis and Juan Aréchaga

Cover Legend

Portrait photos of Hans Spemann (1869-1941) and Hilde Mangold, née Pröscholdt (1898-1924) on a background illustrating a page of H. Mangold´s laboratory notebook. One can clearly appreciate her careful histological analysis of two sections from the famous Um 132 experiment. The induction of a second embryonic axis after heterotransplantation of the upper blastoporal lip in a triton embryo is clearly apparent.


Eddy De Robertis and Juan Aréchaga

Int. J. Dev. Biol. (2001) 45: 0-0

Heritage of the 1924 article by Hans Spemann and Hilde Mangold

Introducing the Spemann-Mangold organizer: experiments and insights that generated a key concept in developmental biology.

K Sander and P E Faessler

Int. J. Dev. Biol. (2001) 45: 1-11

Induction of embryonic primordia by implantation of organizers from a different species. 1923.

H Spemann and H Mangold

Int. J. Dev. Biol. (2001) 45: 13-38

Developmental biology of amphibians after Hans Spemann in Germany.

H Grunz

Int. J. Dev. Biol. (2001) 45: 39-50

Spemann's heritage in Finnish developmental biology.

L Saxén

Int. J. Dev. Biol. (2001) 45: 51-55

Spemann's influence on Japanese developmental biology.

M Asashima and T S Okada

Int. J. Dev. Biol. (2001) 45: 57-65

Contribution of the Belgian school of embryology to the concept of neural induction by the organizer.

H Alexandre

Int. J. Dev. Biol. (2001) 45: 67-72

Contrasting influences of the organizer and induction concepts on the scientific activity of French embryologists.

J C Beetschen and A M Duprat

Int. J. Dev. Biol. (2001) 45: 73-81

Consequences of the Spemann-Mangold organizer concept for embryological research in Russia: personal impressions.

A T Mikhailov and N A Gorgolyuk

Int. J. Dev. Biol. (2001) 45: 83-96

The organizer concept and modern embryology: Anglo-American perspectives.

T J Horder

Int. J. Dev. Biol. (2001) 45: 97-132

Evolution of the organizer and the chordate body plan.

J Gerhart

Int. J. Dev. Biol. (2001) 45: 133-153

Continuity and change: paradigm shifts in neural induction.

S F Gilbert

Int. J. Dev. Biol. (2001) 45: 155-164

Formation and maintenance of the organizer among the vertebrates.

K Joubin and C D Stern

Int. J. Dev. Biol. (2001) 45: 165-175

Organizer and axes formation as a self-organizing process.

H Meinhardt

Int. J. Dev. Biol. (2001) 45: 177-188

Organizer research today

Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer.

E M De Robertis, O Wessely, M Oelgeschläger, B Brizuela, E Pera, J Larraín, J Abreu and D Bachiller

Int. J. Dev. Biol. (2001) 45: 189-197

Formation of a functional morphogen gradient by a passive process in tissue from the early Xenopus embryo.

N McDowell, J B Gurdon and D J Grainger

Int. J. Dev. Biol. (2001) 45: 199-207

A study of Xlim1 function in the Spemann-Mangold organizer.

L Kodjabachian, A A Karavanov, H Hikasa, N A Hukriede, T Aoki, M Taira and I B Dawid

Int. J. Dev. Biol. (2001) 45: 209-218

Making mesoderm--upstream and downstream of Xbra.

J C Smith

Int. J. Dev. Biol. (2001) 45: 219-224

Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway.

J B Wallingford, K M Vogeli and R M Harland

Int. J. Dev. Biol. (2001) 45: 225-227

Generation of the germ layers along the animal-vegetal axis in Xenopus laevis.

H Yasuo and P Lemaire

Int. J. Dev. Biol. (2001) 45: 229-235

Dickkopf1 and the Spemann-Mangold head organizer.

C Niehrs, O Kazanskaya, W Wu and A Glinka

Int. J. Dev. Biol. (2001) 45: 237-240

Siamois cooperates with TGFbeta signals to induce the complete function of the Spemann-Mangold organizer.

M J Engleka and D S Kessler

Int. J. Dev. Biol. (2001) 45: 241-250

The Spemann-Mangold organizer: the control of fate specification and morphogenetic rearrangements during gastrulation in Xenopus.

T Bouwmeester

Int. J. Dev. Biol. (2001) 45: 251-258

Functional analysis of the Xenopus frizzled 7 protein domains using chimeric receptors.

R K Swain, A Medina and H Steinbeisser

Int. J. Dev. Biol. (2001) 45: 259-264

Fox (forkhead) genes are involved in the dorso-ventral patterning of the Xenopus mesoderm.

H El-Hodiri, N Bhatia-Dey, K Kenyon, K Ault, M Dirksen and M Jamrich

Int. J. Dev. Biol. (2001) 45: 265-271

In vitro induction systems for analyses of amphibian organogenesis and body patterning.

T Ariizumi and M Asashima

Int. J. Dev. Biol. (2001) 45: 273-279

The avian organizer.

T Boettger, H Knoetgen, L Wittler and M Kessel

Int. J. Dev. Biol. (2001) 45: 281-287

Nodal signaling and the zebrafish organizer.

A F Schier and W S Talbot

Int. J. Dev. Biol. (2001) 45: 289-297

The role of the homeodomain protein Bozozok in zebrafish axis formation.

L Solnica-Krezel and W Driever

Int. J. Dev. Biol. (2001) 45: 299-310

Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo.

A Perea-Gomez, M Rhinn and S L Ang

Int. J. Dev. Biol. (2001) 45: 311-320

Roles of Sox factors in neural determination: conserved signaling in evolution?

Y Sasai

Int. J. Dev. Biol. (2001) 45: 321-326

Getting your head around Hex and Hesx1: forebrain formation in mouse.

J P Martinez-Barbera and R S Beddington

Int. J. Dev. Biol. (2001) 45: 327-336

The role of Otx2 in organizing the anterior patterning in mouse.

A Simeone and D Acampora

Int. J. Dev. Biol. (2001) 45: 337-345

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity.

S J Kinder, T E Tsang, S L Ang, R R Behringer and P P Tam

Int. J. Dev. Biol. (2001) 45: 347-355

Otx2 and HNF3beta genetically interact in anterior patterning.

O Jin, K Harpal, S L Ang and J Rossant

Int. J. Dev. Biol. (2001) 45: 357-365

The isthmic organizer and brain regionalization.

S Martínez

Int. J. Dev. Biol. (2001) 45: 367-371

Early neurogenesis in Amniote vertebrates.

N M Le Douarin

Int. J. Dev. Biol. (2001) 45: 373-378