Edited by: Robert E. Hammer and Richard R. Behringer
Experimental modification of the germ line in animals has been critical to many recent advances in our understanding of biological phenomena, and the research contributions of Ralph Brinster that enabled and directed this field are depicted in the cover photographs. For details about these experiments and their influence on the field of germ line modification, see "Embryo culture, stem cells and experimental modification of the embryonic genome" by J. Aréchaga in this issue pp. 861-877.
Int. J. Dev. Biol. (1998) 42: 833-839
The coming of age of the transgenic era.
Int. J. Dev. Biol. (1998) 42: 841-846
Transgenic mice--the early days.
Int. J. Dev. Biol. (1998) 42: 847-854
Germ cells and germ cell transplantation.
Int. J. Dev. Biol. (1998) 42: 855-860
Int. J. Dev. Biol. (1998) 42: 861-878
Reflections on the culture of the preimplantation embryo.
Int. J. Dev. Biol. (1998) 42: 879-884
Culture of human preimplantation embryos to the blastocyst stage: a comparison of 3 media.
Int. J. Dev. Biol. (1998) 42: 885-893
Postimplantation mouse development: whole embryo culture and micro-manipulation.
Int. J. Dev. Biol. (1998) 42: 895-902
Mouse chimaeras revisited: recollections and reflections.
Int. J. Dev. Biol. (1998) 42: 903-908
Neurulation in amniote vertebrates: a novel view deduced from the use of quail-chick chimeras.
Int. J. Dev. Biol. (1998) 42: 909-916
Int. J. Dev. Biol. (1998) 42: 917-925
Embryonic stem cells and transgenic mice in the study of hematopoiesis.
Int. J. Dev. Biol. (1998) 42: 927-934
Liver disease and compensatory growth: unexpected lessons from genetically altered mice.
Int. J. Dev. Biol. (1998) 42: 935-942
Thirteen years of manipulating the mouse genome: a personal history.
Int. J. Dev. Biol. (1998) 42: 943-950
Int. J. Dev. Biol. (1998) 42: 951-954
Int. J. Dev. Biol. (1998) 42: 955-976
Immunoglobulin transgenes as targets for somatic hypermutation.
Int. J. Dev. Biol. (1998) 42: 977-982
Analysis of transcriptional regulatory regions in vivo.
Int. J. Dev. Biol. (1998) 42: 983-994
Int. J. Dev. Biol. (1998) 42: 995-1002
The use of transgenic animals in biotechnology.
Int. J. Dev. Biol. (1998) 42: 1003-108
Insertional mutagenesis in transgenic mice generated by the pronuclear microinjection procedure.
Int. J. Dev. Biol. (1998) 42: 1009-1017
Transgenic studies of peripheral and central glia.
Int. J. Dev. Biol. (1998) 42: 1019-1024
Comprehensive mammalian genetics: history and future prospects of gene trapping in the mouse.
Int. J. Dev. Biol. (1998) 42: 1025-1036
Developmental fates of the mouse germ cell line.
Int. J. Dev. Biol. (1998) 42: 1037-1042
The germ cell--the mother of all stem cells.
Int. J. Dev. Biol. (1998) 42: 1043-1050
A systematic molecular genetic approach to study mammalian germline development.
Int. J. Dev. Biol. (1998) 42: 1051-1065
Male germ cell transplantation: present achievements and future prospects.
Int. J. Dev. Biol. (1998) 42: 1067-1073