The International Journal of Developmental Biology

Volume 42 > Issue 7 (Special Issue)

Cover Vol. 42 N. 7

Stem Cells and Transgenesis

Edited by: Robert E. Hammer and Richard R. Behringer

Cover Legend

Experimental modification of the germ line in animals has been critical to many recent advances in our understanding of biological phenomena, and the research contributions of Ralph Brinster that enabled and directed this field are depicted in the cover photographs. For details about these experiments and their influence on the field of germ line modification, see "Embryo culture, stem cells and experimental modification of the embryonic genome" by J. Ar├ęchaga in this issue pp. 861-877.

Introductory papers

Egg culture: the foundation.

R E Hammer

Int. J. Dev. Biol. (1998) 42: 833-839

The coming of age of the transgenic era.

V E Papaioannou

Int. J. Dev. Biol. (1998) 42: 841-846

Transgenic mice--the early days.

R D Palmiter

Int. J. Dev. Biol. (1998) 42: 847-854

Germ cells and germ cell transplantation.

A McLaren

Int. J. Dev. Biol. (1998) 42: 855-860

Embryo culture, stem cells and experimental modification of the embryonic genome. An interview with Professor Ralph Brinster.

Juan Ar├ęchaga

Int. J. Dev. Biol. (1998) 42: 861-878

Embryo culture, nutrition and manipulation

Reflections on the culture of the preimplantation embryo.

J D Biggers

Int. J. Dev. Biol. (1998) 42: 879-884

Culture of human preimplantation embryos to the blastocyst stage: a comparison of 3 media.

J Conaghan, K Hardy, H J Leese, R M Winston and A H Handyside

Int. J. Dev. Biol. (1998) 42: 885-893

Postimplantation mouse development: whole embryo culture and micro-manipulation.

P P Tam

Int. J. Dev. Biol. (1998) 42: 895-902

Stem cells

Mouse chimaeras revisited: recollections and reflections.

A K Tarkowski

Int. J. Dev. Biol. (1998) 42: 903-908

Neurulation in amniote vertebrates: a novel view deduced from the use of quail-chick chimeras.

N M Le Douarin, M A Teillet and M Catala

Int. J. Dev. Biol. (1998) 42: 909-916

Using EC and ES cell culture to study early development: recent observations on Indian hedgehog and Bmps.

L Grabel, S Becker, L Lock, P Maye and T Zanders

Int. J. Dev. Biol. (1998) 42: 917-925

Embryonic stem cells and transgenic mice in the study of hematopoiesis.

S H Orkin

Int. J. Dev. Biol. (1998) 42: 927-934

Liver disease and compensatory growth: unexpected lessons from genetically altered mice.

K M Braun and E P Sandgren

Int. J. Dev. Biol. (1998) 42: 935-942

Modification of the mammalian germline

Thirteen years of manipulating the mouse genome: a personal history.

A Bradley, B Zheng and P Liu

Int. J. Dev. Biol. (1998) 42: 943-950

Imprinting.

D Solter

Int. J. Dev. Biol. (1998) 42: 951-954

Genetics of mouse growth.

A Efstratiadis

Int. J. Dev. Biol. (1998) 42: 955-976

Immunoglobulin transgenes as targets for somatic hypermutation.

U Storb, A Peters, E Klotz, N Kim, H M Shen, J Hackett, B Rogerson, R O'Brien and T E Martin

Int. J. Dev. Biol. (1998) 42: 977-982

Analysis of transcriptional regulatory regions in vivo.

R J MacDonald and G H Swift

Int. J. Dev. Biol. (1998) 42: 983-994

Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis.

G Bergers, D Hanahan and L M Coussens

Int. J. Dev. Biol. (1998) 42: 995-1002

The use of transgenic animals in biotechnology.

K M Ebert

Int. J. Dev. Biol. (1998) 42: 1003-108

Insertional mutagenesis in transgenic mice generated by the pronuclear microinjection procedure.

R P Woychik and K Alagramam

Int. J. Dev. Biol. (1998) 42: 1009-1017

Transgenic studies of peripheral and central glia.

A Messing

Int. J. Dev. Biol. (1998) 42: 1019-1024

Comprehensive mammalian genetics: history and future prospects of gene trapping in the mouse.

B P Zambrowicz and G A Friedrich

Int. J. Dev. Biol. (1998) 42: 1025-1036

Developmental fates of the mouse germ cell line.

Y Matsui

Int. J. Dev. Biol. (1998) 42: 1037-1042

The germ cell--the mother of all stem cells.

P J Donovan

Int. J. Dev. Biol. (1998) 42: 1043-1050

A systematic molecular genetic approach to study mammalian germline development.

K Abe, M S Ko and G R MacGregor

Int. J. Dev. Biol. (1998) 42: 1051-1065

Male germ cell transplantation: present achievements and future prospects.

F X Jiang and R V Short

Int. J. Dev. Biol. (1998) 42: 1067-1073