The International Journal of Developmental Biology

Int. J. Dev. Biol. 40: 817 - 822 (1996)

Vol 40, Issue 4

Special Issue: Developmental Biology of Urodeles

Is retinoic acid an endogenous ligand during urodele limb regeneration?

Published: 30 November -0001

C M Viviano and J P Brockes

Ludwig Institute for Cancer Research, University College London, United Kingdom.


The effects of retinoids on a regenerating urodele limb make them interesting candidates for endogenous ligands during regeneration. We review the evidence for considering this possibility. This includes analysis of retinoids and retinoic acid receptors in the regenerate, and studies on activation of retinoid reporter genes. Recent work has provided evidence that the wound epidermis is a source of 9-cis retinoic acid, and may be a favorable model for studying the synthesis and release of this modulator.

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