Int. J. Dev. Biol. 64: 465 - 469 (2020)
Reciprocal interactions between mesenchymal stem cells and macrophages
Review | Published: 14 December 2020
Abstract
Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.
Keywords
mesenchymal stem cell, MSC, macrophage, MSC therapy, immunomodulation