Int. J. Dev. Biol. 62: 453 - 464 (2018)
Special Issue: Regeneration
The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes
Review | Published: 21 June 2018
Abstract
On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes.
Keywords
reprogramming, regeneration, protection, diabetes