The International Journal of Developmental Biology

Int. J. Dev. Biol. 62: 121 - 126 (2018)

Vol 62, Issue 1-2-3

Special Issue: The Chick Embryo Model System

A snail tale and the chicken embryo

Review | Published: 12 January 2018

M. Angela Nieto

Instituto de Neurociencias, CSIC-UMH, Sant Joan d´Alacant, Spain


Some 25 years ago, a clone was identified that contained the chicken Slug sequences (now called Snail2 ). How could we anticipate at that time how much the chick embryo would help us to understand the ins and outs of cell migration during development and in disease? Indeed, the chick embryo helped us identify Snail2 as the first transcription factor that could induce the epithelial-mesenchymal transition (EMT), key for the migration of embryonic and cancer cells.


chicken embryo, neural crest, gastrulation, tumour progression, evo-devo

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