The International Journal of Developmental Biology

Volume 48 > Issue 5-6 (Special Issue)

Cover Vol. 48 N. 5-6

Invasion in Cancer and Embryonic Development

Edited by: Marc Mareel and Juan Aréchaga

Cover Legend

"I do not understand my images and anyone is free to understand them as he wishes. I have only tried to depict my own dreams..." J.M. Folon. This neo-surrealist painting entitled "Invasion" by Jean-Michel Folon (1934, Brussels, Belgium), with its swirling components against a stable background can be considered as a representation of avid cells breaking through the basement membrane to invade the adjacent stroma. With kind permission from J.-M. Folon (2004)



Marc Mareel and Juan Aréchaga

Int. J. Dev. Biol. (2004) 48: 351-353

Oncogenes, tumor suppresor genes & genetic regulation


Molecular cell biology and cancer metastasis. An interview with Garth Nicolson

Marc Mareel

Int. J. Dev. Biol. (2004) 48: 355-363

Transcriptional regulation of cadherins during development and carcinogenesis

Héctor Peinado, Francisco Portillo and Amparo Cano

Int. J. Dev. Biol. (2004) 48: 365-375

APC dosage effects in tumorigenesis and stem cell differentiation

Claudia Gaspar and Riccardo Fodde

Int. J. Dev. Biol. (2004) 48: 377-386

Activities of invasive cells


Discovery and characterization of the cadherin family of cell adhesion molecules. An interview with Masatoshi Takeichi.

Douglas Sipp

Int. J. Dev. Biol. (2004) 48: 387-396

Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy

Ramsey A. Foty and Malcolm S. Steinberg

Int. J. Dev. Biol. (2004) 48: 397-409

Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies

Alicia R. Folgueras, Alberto M. Pendás, Luis M. Sánchez and Carlos López-Otín

Int. J. Dev. Biol. (2004) 48: 411-424

Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells

Jury M. Vasiliev

Int. J. Dev. Biol. (2004) 48: 425-439

Collective cell migration in morphogenesis and cancer

Peter Friedl, Yael Hegerfeldt and Miriam Tusch

Int. J. Dev. Biol. (2004) 48: 441-449

Invasive growth: a genetic program

Alessandra Gentile and Paolo M. Comoglio

Int. J. Dev. Biol. (2004) 48: 451-456

Invasion signalling pathways

From here to there; a life based on migration. An interview with Isaiah J. Fidler

Ian R. Hart

Int. J. Dev. Biol. (2004) 48: 457-462

N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling

Lara D.M. Derycke and Marc E. Bracke

Int. J. Dev. Biol. (2004) 48: 463-476

The Wnt connection to tumorigenesis

Jürgen Behrens and Barbara Lustig

Int. J. Dev. Biol. (2004) 48: 477-487

The chemokine network in cancer - much more than directing cell movement

Hagen Kulbe, Neil R. Levinson, Fran Balkwill and Julia L. Wilson

Int. J. Dev. Biol. (2004) 48: 489-496

Participation of the host

Brain tumour development and invasion. An interview with Ole Didrik Laerum

Dieter F. Hülser

Int. J. Dev. Biol. (2004) 48: 497-508

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

Alexis Desmoulière, Christelle Guyot and Giulio Gabbiani

Int. J. Dev. Biol. (2004) 48: 509-517

The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines

Ghislain Opdenakker and Jo Van Damme

Int. J. Dev. Biol. (2004) 48: 519-527

Normal embryonic invaders & their malignant counterparts

The migration and differentiation of a chemist entangled in developmental and cancer biology. An interview with Jean-Paul Thiery.

Fred T. Bosman

Int. J. Dev. Biol. (2004) 48: 529-535

Primordial germ cell migration

Kathleen Molyneaux and Christopher Wylie

Int. J. Dev. Biol. (2004) 48: 537-543


Germinal tumor invasion and the role of the testicular stroma

Alejandro Díez-Torre, Unai Silván, Olivier De Wever, Erik Bruyneel, Marc Mareel and Juan Aréchaga

Int. J. Dev. Biol. (2004) 48: 545-557


Tumor invasion and metastasis: getting more basic to come closer to the patient. An interview with Lance A. Liotta.

Vincent Castronovo

Int. J. Dev. Biol. (2004) 48: 559-562

The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes

Adriana Albini, Roberto Benelli, Douglas M. Noonan and Claudio Brigati

Int. J. Dev. Biol. (2004) 48: 563-571

Novel technologies and recent advances in metastasis research

Ivana Crnic and Gerhard Christofori

Int. J. Dev. Biol. (2004) 48: 573-581

Therapeutic aspects


Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention

Suzanne A. Eccles

Int. J. Dev. Biol. (2004) 48: 583-598

Pain control by ionizing radiation of bone metastasis

Luc A.M.-L. Vakaet and Tom Boterberg

Int. J. Dev. Biol. (2004) 48: 599-606