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The International Journal of Developmental Biology

Volume 48 > Issue 5-6 (Special Issue)

Cover Vol. 48 N. 5-6

Invasion in Cancer and Embryonic Development

Edited by: Marc Mareel and Juan Aréchaga

Cover Legend

"I do not understand my images and anyone is free to understand them as he wishes. I have only tried to depict my own dreams..." J.M. Folon. This neo-surrealist painting entitled "Invasion" by Jean-Michel Folon (1934, Brussels, Belgium), with its swirling components against a stable background can be considered as a representation of avid cells breaking through the basement membrane to invade the adjacent stroma. With kind permission from J.-M. Folon (2004)

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Preface

Marc Mareel and Juan Aréchaga

Int. J. Dev. Biol. (2004) 48: 351-353

https://doi.org/10.1387/ijdb.041896mm

Oncogenes, tumor suppresor genes & genetic regulation

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Molecular cell biology and cancer metastasis. An interview with Garth Nicolson

Marc Mareel

Int. J. Dev. Biol. (2004) 48: 355-363

https://doi.org/10.1387/ijdb.041803mm

Transcriptional regulation of cadherins during development and carcinogenesis

Héctor Peinado, Francisco Portillo and Amparo Cano

Int. J. Dev. Biol. (2004) 48: 365-375

https://doi.org/10.1387/ijdb.041794hp

APC dosage effects in tumorigenesis and stem cell differentiation

Claudia Gaspar and Riccardo Fodde

Int. J. Dev. Biol. (2004) 48: 377-386

https://doi.org/10.1387/ijdb.041807cg

Activities of invasive cells

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Discovery and characterization of the cadherin family of cell adhesion molecules. An interview with Masatoshi Takeichi.

Douglas Sipp

Int. J. Dev. Biol. (2004) 48: 387-396

https://doi.org/10.1387/ijdb.041801ds

Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy

Ramsey A. Foty and Malcolm S. Steinberg

Int. J. Dev. Biol. (2004) 48: 397-409

https://doi.org/10.1387/ijdb.041810rf

Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies

Alicia R. Folgueras, Alberto M. Pendás, Luis M. Sánchez and Carlos López-Otín

Int. J. Dev. Biol. (2004) 48: 411-424

https://doi.org/10.1387/ijdb.041811af

Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells

Jury M. Vasiliev

Int. J. Dev. Biol. (2004) 48: 425-439

https://doi.org/10.1387/ijdb.041806jv

Collective cell migration in morphogenesis and cancer

Peter Friedl, Yael Hegerfeldt and Miriam Tusch

Int. J. Dev. Biol. (2004) 48: 441-449

https://doi.org/10.1387/ijdb.041821pf

Invasive growth: a genetic program

Alessandra Gentile and Paolo M. Comoglio

Int. J. Dev. Biol. (2004) 48: 451-456

https://doi.org/10.1387/ijdb.041799ag

Invasion signalling pathways

From here to there; a life based on migration. An interview with Isaiah J. Fidler

Ian R. Hart

Int. J. Dev. Biol. (2004) 48: 457-462

https://doi.org/10.1387/ijdb.041790ih

N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling

Lara D.M. Derycke and Marc E. Bracke

Int. J. Dev. Biol. (2004) 48: 463-476

https://doi.org/10.1387/ijdb.041793ld

The Wnt connection to tumorigenesis

Jürgen Behrens and Barbara Lustig

Int. J. Dev. Biol. (2004) 48: 477-487

https://doi.org/10.1387/ijdb.041815jb

The chemokine network in cancer - much more than directing cell movement

Hagen Kulbe, Neil R. Levinson, Fran Balkwill and Julia L. Wilson

Int. J. Dev. Biol. (2004) 48: 489-496

https://doi.org/10.1387/ijdb.041814hk

Participation of the host

Brain tumour development and invasion. An interview with Ole Didrik Laerum

Dieter F. Hülser

Int. J. Dev. Biol. (2004) 48: 497-508

https://doi.org/10.1387/ijdb.041792dh

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

Alexis Desmoulière, Christelle Guyot and Giulio Gabbiani

Int. J. Dev. Biol. (2004) 48: 509-517

https://doi.org/10.1387/ijdb.041802ad

The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines

Ghislain Opdenakker and Jo Van Damme

Int. J. Dev. Biol. (2004) 48: 519-527

https://doi.org/10.1387/ijdb.041796go

Normal embryonic invaders & their malignant counterparts

The migration and differentiation of a chemist entangled in developmental and cancer biology. An interview with Jean-Paul Thiery.

Fred T. Bosman

Int. J. Dev. Biol. (2004) 48: 529-535

https://doi.org/10.1387/ijdb.041795fb

Primordial germ cell migration

Kathleen Molyneaux and Christopher Wylie

Int. J. Dev. Biol. (2004) 48: 537-543

https://doi.org/10.1387/ijdb.041833km

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Germinal tumor invasion and the role of the testicular stroma

Alejandro Díez-Torre, Unai Silván, Olivier De Wever, Erik Bruyneel, Marc Mareel and Juan Aréchaga

Int. J. Dev. Biol. (2004) 48: 545-557

https://doi.org/10.1387/ijdb.041897ad

Methodology

Tumor invasion and metastasis: getting more basic to come closer to the patient. An interview with Lance A. Liotta.

Vincent Castronovo

Int. J. Dev. Biol. (2004) 48: 559-562

https://doi.org/10.1387/ijdb.041834vc

The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes

Adriana Albini, Roberto Benelli, Douglas M. Noonan and Claudio Brigati

Int. J. Dev. Biol. (2004) 48: 563-571

https://doi.org/10.1387/ijdb.041822aa

Novel technologies and recent advances in metastasis research

Ivana Crnic and Gerhard Christofori

Int. J. Dev. Biol. (2004) 48: 573-581

https://doi.org/10.1387/ijdb.041809ic

Therapeutic aspects

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Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention

Suzanne A. Eccles

Int. J. Dev. Biol. (2004) 48: 583-598

https://doi.org/10.1387/ijdb.041820se

Pain control by ionizing radiation of bone metastasis

Luc A.M.-L. Vakaet and Tom Boterberg

Int. J. Dev. Biol. (2004) 48: 599-606

https://doi.org/10.1387/ijdb.041817lv