The International Journal of Developmental Biology

Volume 48 > Issue 2-3 (Special Issue)

Cover Vol. 48 N. 2-3

Skin Development

Edited by: Danielle Dhouailly

Cover Legend

The cover picture highlights some of the problems in skin development which are currently en route to being resolved: a) how do regular repetitive structures, hairs or feathers, arise during embryogenesis? b) how is the dermis able to induce the formation of an epidermis with cutaneous appendages and their associated stem cells in any epithelium of ectoderm origin? c) how is the architecture of appendages controlled by the dermis? Foreground images: (Left) Feather primordia visualized by in situ staining for Shh (C.M. Chuong). In this example the dorsal feather pattern in a 7 day chick embryo is apparent. (Middle and Right) Examples of hair follicle induction by a wild type mouse embryonic dermis in Rosa 26 mouse amnion and corneal epithelium respectively; hair follicles were visualized by β-gal staining (D. Dhouailly and C. Jahoda). Background image: spiny barbules of a chick-type feather formed by a duck epidermis/chick dermis recombinant (D. Dhouailly).

Early stages: formation of the skin fields

The choice between epidermal and neural fate: a matter of calcium.

Marc Moreau and Catherine Leclerc

Int. J. Dev. Biol. (2004) 48: 75-84

Skin field formation: morphogenetic events.

Danielle Dhouailly, Isabel Olivera-Martinez, Ingrid Fliniaux, Sylvain Missier, Jean P Viallet and Jacques Thélu

Int. J. Dev. Biol. (2004) 48: 85-91

Molecular mechanisms controlling dorsal dermis generation from the somitic dermomyotome.

Isabel Olivera-Martinez, Jacques Thélu and Danielle Dhouailly

Int. J. Dev. Biol. (2004) 48: 93-101

Ventral vs. dorsal chick dermal progenitor specification.

Ingrid Fliniaux, Jean P Viallet and Danielle Dhouailly

Int. J. Dev. Biol. (2004) 48: 103-106

Formation of cutaneous appendages

The different steps of skin formation in vertebrates.

Isabel Olivera-Martinez, Jean P Viallet, Frederic Michon, David J Pearton and Danielle Dhouailly

Int. J. Dev. Biol. (2004) 48: 107-115


Integument pattern formation involves genetic and epigenetic controls: feather arrays simulated by digital hormone models.

Ting-Xin Jiang, Randall B Widelitz, Wei-Min Shen, Peter Will, Da-Yu Wu, Chih-Min Lin, Han-Sung Jung and Cheng-Ming Chuong

Int. J. Dev. Biol. (2004) 48: 117-135

How and when the regional competence of chick epidermis is established: feathers vs. scutate and reticulate scales, a problem en route to a solution.

Fabrice Prin and Danielle Dhouailly

Int. J. Dev. Biol. (2004) 48: 137-148

Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development.

Boris Bardot, Laure Lecoin, Ingrid Fliniaux, Emmanuelle Huillard, Maria Marx and Jean P Viallet

Int. J. Dev. Biol. (2004) 48: 149-156

Spacing patterns on tongue surface-gustatory papilla.

Han-Sung Jung, Keiichi Akita and Jae-Young Kim

Int. J. Dev. Biol. (2004) 48: 157-161

Differentiation of hair follicle and feather

Hair follicle differentiation and regulation.

George E Rogers

Int. J. Dev. Biol. (2004) 48: 163-170

Inherited disorders of the skin in human and mouse: from development to differentiation.

Ryan F L O'Shaughnessy and Angela M Christiano

Int. J. Dev. Biol. (2004) 48: 171-179


The biology of feather follicles.

Mingke Yu, Zhicao Yue, Ping Wu, Da-Yu Wu, Julie-Ann Mayer, Marcus Medina, Randall B Widelitz, Ting-Xin Jiang and Cheng-Ming Chuong

Int. J. Dev. Biol. (2004) 48: 181-191

Integument stem cells

Sharpening the focus; the business of epithelial cell biology. An interview with Chris Potten.

David Pearton

Int. J. Dev. Biol. (2004) 48: 193-196

Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis.

David J Pearton, Corinne Ferraris and Danielle Dhouailly

Int. J. Dev. Biol. (2004) 48: 197-201

Derivation of keratinocyte progenitor cells and skin formation from embryonic stem cells.

Daniel Aberdam

Int. J. Dev. Biol. (2004) 48: 203-206

From Drosophila to Vertebrates

Genetic control of epidermis differentiation in Drosophila.

François Payre

Int. J. Dev. Biol. (2004) 48: 207-215

Skin development in bony fish with particular emphasis on collagen deposition in the dermis of the zebrafish (Danio rerio).

Dominique Le Guellec, Ghislaine Morvan-Dubois and Jean-Yves Sire

Int. J. Dev. Biol. (2004) 48: 217-231

Scale development in fish: a review, with description of sonic hedgehog (shh) expression in the zebrafish (Danio rerio).

Jean-Yves Sire and Marie-Andrée Akimenko

Int. J. Dev. Biol. (2004) 48: 233-247


Evo-Devo of amniote integuments and appendages.

Ping Wu, Lianhai Hou, Maksim Plikus, Michael Hughes, Jeffrey Scehnet, Sanong Suksaweang, Randall Widelitz, Ting-Xin Jiang and Cheng-Ming Chuong

Int. J. Dev. Biol. (2004) 48: 249-270