The International Journal of Developmental Biology

Int. J. Dev. Biol. 42: 393 - 401 (1998)

Vol 42, Issue 3

Special Issue: Developmental Genetics of Drosophila

Segmentation and specification in the branchial region of the head: the role of the Hox selector genes

Published: 30 November -0001

F M Rijli, A Gavalas and P Chambon

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Strasbourg.


Hox genes are segmentally expressed in the developing vertebrate hindbrain, neural crest cells and pharyngeal arches suggesting an important role in patterning these structures. Here we discuss the cellular and molecular mechanisms controlling segmentation and specification in the branchial region of the head. In addition, based on the recent phenotypical and molecular analysis of loss-of-function mutants in the mouse, we speculate that Hox genes may act like Drosophila selector genes in this system.

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