The International Journal of Developmental Biology

Int. J. Dev. Biol. 42: 325 - 333 (1998)

Vol 42, Issue 3

Special Issue: Developmental Genetics of Drosophila

Interactions between Wingless and Notch during the assignment of cell fates in Drosophila

Published: 1 April 1998

A Martinez Arias

Department of Zoology, University of Cambridge, United Kingdom.


A large number of observations suggest that, during Drosophila development there are close functional interactions between the activity of Notch receptor and that of a signaling molecule encoded by wingless gene. In this essay, I summarize these interactions and discuss the possibility that Wingless acts as a ligand for Notch as part of a switch that is iteratively involved in the assignation of cell fates during development.

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