The International Journal of Developmental Biology

Int. J. Dev. Biol. 42: 299 - 304 (1998)

Vol 42, Issue 3

Special Issue: Developmental Genetics of Drosophila

Molecular recapitulation: the growth of the vertebrate retina

Published: 1 April 1998

W A Harris and M Perron

Department of Anatomy, University of Cambridge, United Kingdom.


In postembryonic lower vertebrates, the ciliary marginal zone (CMZ) of the retina is a continuously growing zone in the central nervous system. By studying the cellular and molecular biology of the cells in this region, we have discovered that the CMZ can be divided into several zones, from peripheral to central, which reflect different stages of development of retinal stem cells. Based on the behavior of the cells and on the genes expressed in different regions, we propose here that cellular development in the CMZ recapitulates in space what happens in embryonic retinal development in time.

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