Int. J. Dev. Biol. 41: 639 - 642 (1997)

Vol 41, Issue 4

Apparent normal phenotype of Fgf6-/- mice

Published: 1 August 1997

F Fiore, J Planche, P Gibier, A Sebille, O deLapeyrière and D Birnbaum

Laboratoire d'Oncologie Moléculaire, U119 INSERM, Marseille, France.

Abstract

To study the role of the sixth member of the FGF (fibroblast growth factor) family whose expression is restricted to skeletal muscle, we have derived mouse mutants with a homozygous disruption of the Fgf6 gene. The animals are viable, fertile and apparently normal, indicating that FGF6 is not required for vital functions in the laboratory mouse.