The International Journal of Developmental Biology

Int. J. Dev. Biol. 41: 291 - 297 (1997)

Vol 41, Issue 2

Special Issue: Vertebrate Development in vitro

Mouse embryos in culture: models for understanding diabetes-induced embryopathies and gene function

Published: 30 November -0001

T W Sadler

University of North Carolina, Department of Cell Biology and Anatomy, UNC Birth Defects Center, Chapel Hill 27599, USA.


Both the metabolic studies on diabetes and the genetic studies using antisense oligodeoxynucleotides clearly demonstrate the importance and usefulness of rodent whole embryo culture. Without this technique, these studies would be impossible and, consequently, our knowledge of both normal and abnormal development would not be as advanced as it is today. The culture system fills a unique niche in studies in the fields of developmental biology and teratology and these sciences would have been less well served without Dr. New's contribution.

Full text in web format is not available for this article. Please download the PDF version.