The International Journal of Developmental Biology

Int. J. Dev. Biol. 39: 933 - 938 (1995)

Vol 39, Issue 6

Cell surface alterations in embryonic tissues exposed to RGD-peptides: selective expression

Published: 1 December 1995

J W Lash, K M Yamada and R Bellairs

Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, USA.


Whole animal studies have implicated cell adhesion molecules in a diverse array of developmental processes. The present study reports on the morphological effects of RGD-related peptides on the cell surface of various living chick embryonic tissues. We report a novel and characteristic plasma membrane reaction that is caused by treatment with different RGD-peptides. Not only does each peptide evoke a response in certain tissues and not in others, but each brings about a specific type of plasma membrane reaction (bleb). Although the mechanisms are unknown, the specificity of this phenomenon suggests that it could provide a window into new surface interactions in morphogenetic systems.

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