The International Journal of Developmental Biology

Int. J. Dev. Biol. 39: 895 - 908 (1995)

Vol 39, Issue 6

Tumor suppressor genes as negative growth regulators in development and differentiation

Published: 1 December 1995

D H Gutmann

Department of Neurology, Washington University School of Medicine, St. Louis, USA.


Tumor suppressor genes have received much attention for their roles in the development of human malignancies. However, their gene products (proteins) function as negative growth regulators and are highly expressed in many tissues during embryonic development, suggesting that they might function as critical proteins in differentiation and development. The evidence implicating tumor suppressor proteins in cellular differentiation and embryonic development will be presented with special attention to the neurofibromatosis 1, neurofibromatosis 2, and tuberous sclerosis 2 gene products.

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