The International Journal of Developmental Biology

Int. J. Dev. Biol. 40: 221 - 227 (1996)

Vol 40, Issue 1

Special Issue: Developmental Biology in Germany

Large scale genetics in a small vertebrate, the zebrafish

Published: 1 February 1996

P Haffter and C Nüsslein-Volhard

Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany.


The systematic isolation and characterization of mutants in Drosophila has enormously facilitated the analysis of molecular mechanisms underlying developmental pathways in the embryo. A similar approach is presently being used to study embryonic development of the zebrafish, which is becoming a mainstream model organism for vertebrate development. With its genetic versatility and sophisticated embryology, zebrafish offers the possibility to rapidly increase our knowledge of vertebrate development and add to what we have learned from other vertebrate model organisms.

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