The International Journal of Developmental Biology

Int. J. Dev. Biol. 37: 227 - 235 (1993)

Vol 37, Issue 1

Special Issue: Developmental Aspects of Neoplasia

Expression of E-cadherin in embryogenetic ingression and cancer invasion

Published: 1 March 1993

M Mareel, M Bracke, F Van Roy and L Vakaet

Department of Radiotherapy and Nuclear Medicine, University Hospital, Ghent, Belgium.


Homophilic interactions of E-cadherin serve the organization of embryonic and adult epithelia and counteract cancer invasion. The role of E-cadherin as an invasion-suppressor molecule has been demonstrated cancer. Regulation of embryonic ingression and cancer invasion via E-cadherin occurs at transcriptional, translational and post-translation levels.

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