Expression of E-cadherin in embryogenetic ingression and cancer invasion
Published: 1 March 1993
M Mareel, M Bracke, F Van Roy and L Vakaet
Department of Radiotherapy and Nuclear Medicine, University Hospital, Ghent, Belgium.
Homophilic interactions of E-cadherin serve the organization of embryonic and adult epithelia and counteract cancer invasion. The role of E-cadherin as an invasion-suppressor molecule has been demonstrated cancer. Regulation of embryonic ingression and cancer invasion via E-cadherin occurs at transcriptional, translational and post-translation levels.