The International Journal of Developmental Biology

Int. J. Dev. Biol. 37: 111 - 116 (1993)

Vol 37, Issue 1

Special Issue: Developmental Aspects of Neoplasia

Two proto-oncogenes that play dual roles in embryonal cell growth and differentiation

Published: 1 March 1993

E D Adamson

La Jolla Cancer Research Foundation, CA 92037.


The function of growth factors in early development is reviewed. Special emphasis is on the epidermal growth factor and its receptor, and on the c-fos and its family of transcriptional factor proteins, which play an important role in modulating the growth and differentiation of early embryos and embryonal carcinoma cells.

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