D Deutsch, A Palmon, L Dafni, J Catalano-Sherman, M F Young and L W Fisher
Department of Oral Biology, Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
This paper reviews the primary structure, characteristics and possible function of tuftelin/enamelin protein. It describes the distribution of tuftelin in the ameloblast cell and in the extracellular enamel matrix, employing high resolution protein-A gold immunocytochemistry. The chromosomal localization of the human tuftelin gene and its possible involvement in autosomally linked Amelogenesis Imperfecta, the most common hereditary disease of enamel, is also discussed.