The International Journal of Developmental Biology

Int. J. Dev. Biol. 33: 245 - 259 (1989)

Vol 33, Issue 2

Production of monoclonal antibodies against mouse molar papilla cells

Published: 1 June 1989

G Zidan and J V Ruch

Institut de Biologie Médicale, Faculté de Médecine, Université Louis Pasteur, Strasbourg, France.


To develop markers for the analysis of the molecular mechanisms of dental papilla cells differentiation, 10 monoclonal antibodies were produced against trypsin-isolated mouse molar dental papilla cells. These antibodies identify matrix components, cell membrane associated antigens and intracellular-constituents. Changes of the staining patterns were correlated with a typological hierarchy of dental papilla cells and with terminal differentiation of odontoblasts.

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