The International Journal of Developmental Biology

Int. J. Dev. Biol. 47: 685 - 693 (2003)

Vol 47, Issue 7-8

Special Issue: Evolution & Development

Adaptive walks in a gene network model of morphogenesis: insights into the Cambrian explosion

Published: 30 November -0001

Ricard V Solé, Pau Fernández and Stuart A Kauffman

ICREA-Complex Systems Lab, Universitat Pompeu Fabra (GRIB), Barcelona, Spain.


The emergence of complex patterns of organization close to the Cambrian boundary is known to have happened over a (geologically) short period of time. It involved the rapid diversification of body plans and stands as one of the major transitions in evolution. How it took place is a controversial issue. Here we explore this problem by considering a simple model of pattern formation in multicellular organisms. By modeling gene network-based morphogenesis and its evolution through adaptive walks, we explore the question of how combinatorial explosions might have been actually involved in the Cambrian event. Here we show that a small amount of genetic complexity including both gene regulation and cell-cell signaling allows one to generate an extraordinary repertoire of stable spatial patterns of gene expression compatible with observed anteroposterior patterns in early development of metazoans. The consequences for the understanding of the tempo and mode of the Cambrian event are outlined.

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