The International Journal of Developmental Biology

Int. J. Dev. Biol. 44: 327 - 330 (2000)

Vol 44, Issue 3

Expression patterns of follistatin and two follistatin-related proteins during mouse development

Published: 1 April 2000

E De Groot, A Feijen, D Eib, A Zwijsen, H Sugino, G Martens and A J Van Den Eijnden-Van Raaij

Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht.


We compared the expression patterns of follistatin and two follistatin-related proteins (FRP and m7365) during early mouse development. m7365 is expressed continuously during preimplantation development, in contrast to FRP and follistatin. At early postimplantation stages, follistatin and 7365 are expressed from E6.0, while FRP is detected from E7.5 onwards. Although there is some overlap between the expression of these genes in the primitive streak and somites, their overall expression patterns are distinct.

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