The International Journal of Developmental Biology

Int. J. Dev. Biol. 51: 255 - 258 (2007)

Vol 51, Issue 3

Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation

Developmental Expression Pattern | Published: 1 April 2007

Terje Svingen, Annemiek Beverdam, Pali Verma, Dagmar Wilhelm and Peter Koopman*

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia


Aard (alanine and arginine rich domain) is a gene of unknown function, previously reported to show sexually dimorphic expression in fetal mouse gonads. Here we describe the spatio-temporal expression profile of Aard during gonad development. The period of elevated mRNA expression coincides with early differentiation of the testis and is limited to Sertoli cells of the developing testis cords. Although low levels of Aard transcripts were detected in other tissues by quantitative RT-PCR assays, high levels of Aard expression is specific to the testis in both embryonic and adult mice.


Aard, gonad, sex differentiation, testis cord, Sertoli cell

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