The International Journal of Developmental Biology

Int. J. Dev. Biol. 49: 209 - 220 (2005)

Vol 49, Issue 2-3

Special Issue: The Nogent Institute

Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage

Published: 1 May 2005

Barbara Le Bras, Elli Chatzopoulou, Katharina Heydon, Salvador Martínez1, Katzuhiko Ikenaka2, Laetitia Prestoz3, Nathalie Spassky, Bernard Zalc and Jean-Léon Thomas*

Unité Mixte de Recherche INSERM U-711 & UPMC, Paris, France, 1Instituto de Neurociencias, Universidad Miguel Hernandez, San Juan de Alicante, Spain, 2National Institut for Physiological Sciences, Okazaki National Research Instituts, Okazaki, Aichi, Japan and 3PBS- Laboratoire des Biomembranes et Signalisation Cellulaire, Université de Poitiers, France


Oligodendrocytes are the myelin forming cells of the central nervous system. Over the last decade, their development in the embryonic brain and spinal cord has been documented following the discovery of early oligodendroglial markers. This review highlights the fundamental results obtained on the specification and migration of oligodendroglial cells and illustrates our advances in the knowledge of the cell lineage expressing plp (proteolipid protein), one of the early oligodendroglial genes.


embryonic brain, oligodendrocyte, specification, migration, plp/dm-20

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